尿α1微球蛋白和β2微球蛋白对2-4期慢性肾病患者的诊断价值  

Value of urine α_1 microglobumin and β_2 microglobumin for the diagnosis of stage 2-4 chronic kidney disease

作　　者：向代军[1] 张洪瑞[1,2] 白洁[1] 王璐[1] 马飞[1] 彭文红[1] 马骏龙[1] 王成彬[1] 

机构地区：[1]解放军总医院临床检验科,北京100853 [2]温州医科大学生命检验学院,浙江温州325000

出　　处：《检验医学与临床》2014年第8期1011-1012,1015,共3页Laboratory Medicine and Clinic

基　　金：国家科技支撑计划项目(2013BAI17B05);全军医学科研十二五计划项目(AWS11Z005-4)

摘　　要：目的：探讨尿α1、β2微球蛋白在2～4期慢性肾病患者中诊断价值。方法解放军总医院2011年12月至2013年5月肾内科的134例住院患者和50例健康体检者的尿α1、β2微球蛋白和其他肾功能指标进行检测分析，采用MDRD公式进行肾小球滤过率计算。结果慢性肾病组尿α1、β2微球蛋白水平明显高于健康对照组，差异有统计学意义（P＜0．01）。2～4期慢性肾病患者中尿α1、β2微球蛋白结果呈明显升高趋势，其差异有统计学意义（P＜0．05）。尿α1、β2微球蛋白在3a和3b期中结果有明显差异，3a期尿α1微球蛋白（20．00±18．9）mg/L、3b期（40．5±28．5）mg/L ；3a期β2微球蛋白（4．1±4．0）mg/L、3b期（10．0±8．7）mg/L。相关分析显示，尿α1、β2微球蛋白与肌酐呈显著正相关，与eGFR呈显著负相关。结论尿α1、β2微球蛋白是用于评价慢性肾脏疾病肾功能较好的实验室指标。Objective To explore the value of urine α1 microglobumin and β2 microglobumin for the diagnosis of stage 2-4 chronic kidney disease （CKD） .Methods Urineα1 microglobumin ,β2 microglobumin and the other indi-cator related to kidney function were analyzed in 134 patients with CKD （ CKD group） and 50 healthy subjects （con-trol group） from December 2011 to May 2013 .The estimated glomerular filtration rate （eGFR） was calculated by u-sing the modified Modification of Diet in Renal Disease （MDRD） equation .Results Levels of urineα1 microglobumin andβ2 microglobumin in CKD group were significantly higher than those in control group （P＆lt;0 .01） .Levels of urineα1 microglobumin andβ2 microglobumin were increased with the elevation of disease stages of CKD from stage 2 to stage 4 .Levels of urine α1 microglobumin were （20 .00 ± 18 .9） mg/L in stage 3a and （40 .5 ± 28 .5）mg/L in stage 3b ,and levels of urine β2 microglobumin were （4 .1 ± 4 .0）mg/L in stage 3a and （10 .0 ± 8 .7）mg/L in stage 3b ,the differences between the two groups were significant .Correlation analysis indicated that levels of urine α1 microglobu-min andβ2 microglobumin were positively correlated with to creatinine ,negatively correlated with eGFR .Conclusion Urineα1 microglobumin andβ2 microglobumin might be useful indicators for the assessment of renal damage in pa-tients with CKD .

关 键 词：尿Α1微球蛋白 尿Β2微球蛋白 慢性肾病 

分 类 号：R587.2[医药卫生—内分泌]