门冬氨酸鸟氨酸对原发性肝癌放疗患者血管内皮生长因子的影响  

Effect of Ornithine Aspartate intervention on vascular endothelial growth factor of patients with primary hepatic carcinoma radiotherapy

作　　者：杨光辉[1] 薛涛[1] 马博[1] 李萍[1] 俞雪梅[1] 莫建民[1] 许丽萍[1] 

机构地区：[1]湖州师范学院附属第一医院药剂科,浙江湖州313000

出　　处：《中国医药导报》2014年第15期65-67,71,共4页China Medical Herald

基　　金：浙江省医药卫生平台骨干人才计划项目(编号2013RCB017)

摘　　要：目的 评价门冬氨酸鸟氨酸治疗原发性肝癌放射性肝损伤的效果，并观察门冬氨酸鸟氨酸对原发性肝癌放疗患者血清血管内皮生长因子（VEGF）水平的影响。方法 选取湖州师范学院附属第一医院2011年9月～2013年12月收治的肝癌患者120例，分为对照组及观察组，每组各60例。对照组患者在放疗时接受保肝、保胃和止血处理，观察组则在对照组的基础上联合使用门冬氨酸鸟氨酸。对两组患者的肝功能改变情况进行生化检测，以判定疗效。并采用酶联免疫吸附法（ELISA）对血清中VEGF浓度进行检测。结果 两组患者都顺利的完成了放疗，临床症状得到了明显的改善。观察组明显改善率[46．67％（28／60）]高于对照组明显改善率[26．67％（16／60）]，差异有统计学意义（P〈0．05）。观察组患者治疗后14d肝功能各项观察指标均明显高于治疗前，处于正常范围，差异有统计学意义（P〈0．05）。治疗后，观察组VEGF水平[（173．2±35．8）pg/mL]低于对照组VEGF水平[（267．5±37．1）pg/mL]，差异有高度统计学意义（P〈0．01）。结论 门冬氨酸鸟氨酸在治疗肝癌放射性肝损伤方面具有一定优势，能够促进胆红素代谢，减少肝细胞损伤，有效保护肝脏，并能显著改善原发性肝癌放疗患者血清VEGF水平。Objective To evaluate the efficacy of Ornithine Aspartate in the treatment of primary hepatic carcinoma ra diation-induced liver injury. And to observe the influence of Ornithine Aspartate on serum vascularendothelial growth factor （VEGF） level in patients of primary hepatic carcinoma with radiotherapy. Methods 120 cases of liver cancer patients in the First Affiliated Hospital of Huzhou Teachers College from September 2011 to December 2013 were select- ed and divided into control group and observation group, with 60 cases in each group. The patients in control group were treated with liver, stomach and hemostatic treatment in the radiotherapy. The observation group was treated with Ornithine Aspartate on the basis of the control group method. The change of liver biochemical function was tested to determine the curative effect. The serum concentration of VEGF was detected using the enzyme-linked immunosorbent assay （ELISA）. Results Patients of two groups were successfully completed the treatment, the clinical symptoms improved obviously. Significant improvement rate of the observation group was [46.67% （28/60）] was more than that of the control group [26.67% （16/60）], the difference was statistically significant （P 〈 0.05）. 14 d after treatment, liver function indexes of patients in the observation group were significantly higher than that before treatment, all in the normal range, the differences were statistically significant （P 〈 0.05）. After treatment, the level of VEGF in the observation group [（173.2±35.8） pg/mL] was lower than that of the control group [（267.5±37.1） pg/mL], the difference was statistically sig- nificant （P 〈 0.01）. Conclusion Ornithine Aspartate has certain advantages in the treatment of radiation-induced liver injury liver, it can promote the metabolism of bilirubin, reduce liver cell damage, protect the liver, and can significantly improve the level of serum VEGF in patients with primary hepatic carcinoma about radiotherapy.

关 键 词：原发性肝癌 门冬氨酸鸟氨酸 放射性肝损伤 血清 血管内皮生长因子 

分 类 号：R285.6[医药卫生—中药学] R735.7[医药卫生—中医学]