氟西汀治疗老年高血压伴抑郁症患者的效果  

Effects of Fluoxetine on hypertension among the elderly with hypertension and depression

作　　者：张弭[1] 黄健[1] 莫新玲[2] 

机构地区：[1]桂林医学院基础医学院,广西桂林541005 [2]桂林医学院附属医院心血管内科,广西桂林541005

出　　处：《中国医药导报》2014年第14期70-73,共4页China Medical Herald

摘　　要：目的探讨氟西汀用于老年高血压并发抑郁症的临床降压疗效。方法将70例老年高血压伴抑郁症患者随机分为对照组和治疗组,各35例。对照组仅接受常规降压治疗:硝苯地平缓释片10 mg,口服,bid;治疗组在对照组治疗基础上给予抗抑郁治疗:氟西汀20 mg,口服,qd。疗程共8周。分别于8周内对两组的血压、抑郁症状及生活质量进行评估。结果两组收缩压及舒张压治疗前后比较差异均有统计学意义(治疗组:P<0.01;对照组:P<0.05),两组间收缩压及舒张压治疗后比较差异均有高度统计学意义(P<0.01);治疗组降压总有效率(92.29%)要高于对照组(45.71%)(P<0.05),其中治疗组显效率(54.29%)要明显高于对照组(17.14%)(P<0.05);治疗组HAMD评分逐渐减小,与治疗前比较差异有统计学意义(P<0.05或P<0.01),8周后HAMD-24减分率为57.29%(>50%),具有临床疗效;对照组HAMD-24评分治疗前后比较差异无统计学意义(P>0.05);两组间HAMD-24评分于4周及8周后差异有高度统计学意义(P<0.01);治疗组生活质量各项评分及总分治疗前后比较差异均有高度统计学意义(P<0.01),而对照组差异无统计学意义(P>0.05),两组治疗后比较差异有高度统计学意义(P<0.01)。结论氟西汀治疗老年高血压患者并发抑郁症具有显著的效果。Objective To observe the effects of Fluoxetine on hypertension among the elderly with hypertension and depression. Methods 70 elderly patients were randomly divided into treatment and control group, each of 35 patients. The control group only accepted antihypertensive therapy： Nifedipine 10 mg, oral bid; the treatment group accepted antihypertensive and antidepressant for treatment： Fluoxetine 20 mg oral, qd. The duration of treatment was 8 weeks. The blood pressure, depressive and life quality score of 2 groups in 8 weeks were compared. Results The differences of diastolic blood pressure and systolic blood pressure of each group were statistically significant before and after treatment （treatment group： P 〈 0.01; control group： P〈 0.05）; the differences of DBP and SBP in two groups were statistically significant （P 〈 0.01）; effective rate of lowering blood pressure in treatment group （92.29%） was much higher than control group （45.71%） （P 〈 0.05）, obvious effective of lowering blood pressure was even better （treatment group： 54.29%; control group： 17.14%） （P 〈 0.05）; the scores of HAMD-24 were decreased and had statistically significant difference before and after treatment in treatment group （P 〈 0.05 or P 〈 0.01）, reducing score rate of HAMD-24 was 57.29% （〉 50%） after 8 weeks in treatment group, and had clinical efficacy; the difference of scores of HAMD-24 before and after treatment in control group was not statistically significant （P 〉 0.05）; the differences of scores of HAMD-24 in two groups were statistically significant after 4 weeks and 8 weeks （P 〈 0.01）; the differences of scores of each part and total scores in quality of life before and after treatment in treatment group were statistically significant （P 〈 0.01）, which were not statistically significant in control group （P 〉 0.05）, there were statistically significant differences after treatment in two groups （P 〈 0.01）. Conclusion Fluoxetine for elderly p

关 键 词：高血压 抑郁症 氟西汀 

分 类 号：R544.1[医药卫生—心血管疾病] R749.3[医药卫生—内科学]