肺炎支原体感染患儿发生肺外并发症的影响因素研究  

Study on risk factors responsible for extrapulmonary complications in pediatric patients with Mycoplasma pneumoniae pneumonia

作　　者：孙菲[1] 

机构地区：[1]江苏省张家港市第一人民医院儿科,江苏张家港215600

出　　处：《临床和实验医学杂志》2014年第9期748-751,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨肺炎支原体肺炎(MPP)发生肺外并发症的影响因素。方法选择2010年1月至2013年6月收住院25例合并肺外并发症的MPP临床资料,以同期年龄相近的35例无肺外并发症的MPP患儿作为对照,比较两组患儿的年龄、性别、体温、热程、胸片或肺部CT病变部位、白细胞总数、中性粒细胞计数、C反应蛋白(CPR)及发病后开始应用大环内酯类抗生素的时间等。结果肺外并发症发生率为41.7%;对可能影响肺外并发症发生的9种危险因素进行单因素分析,结果显示两组的CRP(P<0.05)、中性粒细胞计数(P<0.05)、肺部实变影(P<0.05)和发病超过7 d使用大环内酯类抗生素(P<0.05)相比差异均有统计学意义。经Logistic多因素分析显示:CRP、中性粒细胞计数、发病超过7 d使用大环内酯类抗生素是肺外并发症发生的独立危险因素。结论 MPP肺外并发症可存在各个系统,严重者可造成多系统脏器损害。CRP、中性粒细胞计数和大环内酯类抗生素的延迟使用为发生肺外并发症的危险因素。Objective To explore the risk factors of extrapulmonary complications in pediatric patients with Mycoplasma pneumoniae pneu-monia（ MPP）. Methods The clinical data of extrapulmonary complications in 25 inpatients with MPP during January 2010 to June 2013 and 35 age-matched patients with MPP without extrapulmonary complications were analyzed and compared. The comparison was made between these 2 groups in age,gender,fever,manifestations of pneumonia on X-ray or CT scanning,white blood cell count,neutrophil count,C reaction protein（CRP） and application of macrolide drugs etc. Results The results of analysis indicated that the related risk factors included CRP（ P 〈0. 05）,neutrophil count（ P 〈0. 05）,lung patchy shadow（ P 〈0. 05）and application of macrolide drugs more than 7 days（ P 〈0. 05）. Logistic multivariate analy-sis indicated that CRP,neutrophil count and application of macrolide drugs over 7 days were relative independent risk factors. Conclusion Ex-trapulmonary complications with MPP can be involved in many systems of the body. In severe cases,multi-organs can be involved. CRP,neutrophil count and application of macrolide drugs over 7 days are risk factors responsible for the occurrence of extrapulmonary complications.

关 键 词：肺炎支原体 肺炎 肺外并发症 危险因素 

分 类 号：R725.6[医药卫生—儿科]