紫甘薯提取物对更年期大鼠神经递质及氧化应激的影响  

Effect of purple sweet potato extracts on neurotransmitter and oxidative stress of climacteric rats

作　　者：王婷婷[1] 吕晓玲[1] 张婷婷[1] 李凯[1] 魏曼[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《食品科技》2014年第5期213-216,共4页Food Science and Technology

基　　金：科技部农业科技成果转化资金项目(2011GB2B000015)

摘　　要：为探究紫甘薯提取物（Purplesweetpotatoextracts，PSPE）对更年期大鼠下丘脑神经递质及氧化应激的影响，以11～12月龄雌性SD大鼠作为自然更年期模型，将其分为更年组、阳性对照组和PSPE低、中、高剂量组，分别连续8周饲喂基础饲料、大豆异黄酮和不同剂量的PSPE。另选取3-4月龄大鼠作为青年对照组。检测下丘脑组织中5-羟色胺（5-HT）和多巴胺（DA）含量、单胺氧化酶（MAO）活力，计算5-HT／DA；血清和肝组织中总超氧化物歧化酶（T—SOD）、过氧化氢酶（CAT）活力，丙二醛（MDA）含量。PSPE可以显著降低更年期大鼠5-HT含量（P〈0．01），升高DA含量，使5-HT／DA比值降低接近青年组，显著降低MAO活力（P〈0．01），不同程度提高血清及肝组织中T-SOD、CAT活力，降低MDA含量。紫甘薯提取物可以通过调节下丘脑神经递质含量、增强机体抗氧化能力改善神经系统紊乱缓解更年期综合症。The influence of purple sweet potato extracts （PSPE） on hypothatamus neurotransmitter and oxidative stress in climacteric rats was studied. The 11-12 mouths of age female rats were divided into climacteric group, positive control group and PSPE group. They were feed with basic food, soy isoflavone and PSPE for 8 weeks. The 3-4 mouths of age female rats were divided into youth control group. The 5-HT, DA, 5-HT/DA and MAO in hypothalamus as well as T-SOD, CAT, MDA in serum and liver were measured. The PSPE could decrease 5-HT （P〈0.01）, MAO （P〈0.01）, increase DA and make the radio of 5-HT/DA near to that of youth control group, increase T-SOD, CAT, decrease MDA in serum and liver. The PSPE could adjust hypothalamus neurotransmitter, increase body antioxidation capacity to improve nervous system disorders and climacteric syndrome.

关 键 词：紫甘薯提取物 大鼠 单胺类神经递质 氧化应激 

分 类 号：R285[医药卫生—中药学]