p21基因与哺乳动物器官再生相关性研究进展  

Research Progress of Relationship between p21 Gene and Mammalian Regeneration

作　　者：郭倩倩[1,2] 王大涛[2] 褚文辉[2] 赵海平[2] 孙红梅[2] 李春义[2] 

机构地区：[1]江苏科技大学,江苏镇江212018 [2]中国农业科学院特产研究所,吉林省特种经济动物分子生物学国家重点实验室,吉林长春130112

出　　处：《中国畜牧兽医》2014年第5期171-176,共6页China Animal Husbandry & Veterinary Medicine

基　　金：973前期研究专项(2011CB111500);吉林省自然科学基金(20101575)

摘　　要：自然界中很多低等无脊椎动物及有尾目两栖动物都存在组织或附属器官再生现象,而哺乳动物中这种能力却是少见的。近年来随着具有器官再生能力的MRL试验小鼠的发现,越来越多的试验证实哺乳动物也具有器官再生能力,这为临床上的损伤修复和肢体再生带来了新希望。组织、器官的再生离不开细胞增殖,细胞增殖离不开细胞周期,p21蛋白作为细胞周期的重要调控因子,在最新研究中发现,普通试验小鼠敲除p21基因后具有了同MRL试验小鼠一样的器官再生能力,确定了p21蛋白与再生有着密切联系。文章对p21基因与哺乳动物再生的关系作一综述。Animals＇ capability of regenerating multiple tissue types, organs, and appendages after injury are common among invertebrates and urodele amphibians, but notably such regenerative capacity is rare in mammals. Recently, accumulating evi- dence has proved that mammals may also have regenerative property with the discovery of MRL mouse, and it brings new hope for clinical therapies. The regeneration of appendages depends on cells proliferation, at the same time, cells proliferation de pends on cell cycle, so as one of the cell cycle regulatory proteins, we found the deletion of p21 gene could actually result in full MRL epimorphic regeneration phenotype in a new study, providing a firm link between p21 protein and tissue regeneration. This article reviewed the fields of tissue regeneration and p21 protein, and introduced the relationship between tissue regeneration and p21 protein.

关 键 词：再生 P21基因 哺乳动物 MRL 

分 类 号：Q78[生物学—分子生物学]