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作 者:陈咏君[1] 陈咏玫[2] 张立群[3] 夏莉[1] 吴丽霞[1] 郭晶[1]
机构地区:[1]沈阳医学院附属第二医院,辽宁沈阳110002 [2]北京海淀妇幼保健院 [3]沈阳医学院
出 处:《中国医学创新》2014年第12期80-82,共3页Medical Innovation of China
基 金:沈阳医学院科技基金项目(2013020);辽宁省教育厅科学技术研究项目(L2013399)
摘 要:目的:了解铜绿假单胞菌的感染情况及其耐药性,为临床合理应用抗生素提供科学依据。方法:收集本院临床分离铜绿假单胞菌,分析其科室分布、标本来源及耐药情况。结果:铜绿假单胞菌主要分布于干诊三病房(53.9%),主要以痰液分离最多(91.3%);其耐药率分别为:复方新诺明(100%)、头孢噻肟(83.94%)、庆大霉素(53.42%)、头孢他啶(51.83%)、氨曲南(50.55%)、头孢西林(50.27%)、环丙沙星(48.62%)、左氧氟沙星(44.95%)、妥布霉素(43.38%)、头孢吡肟(42.66%)、阿米卡星(26.30%)、哌拉西林/他唑巴坦(22.57%)、美罗培南(16.90%)、亚胺培南(14.39%)。结论:铜绿假单胞菌的耐药机制复杂,应加强医院耐药菌株的监测,指导临床合理使用抗生素,采取有效的防范措施最大限度减少铜绿假单胞菌感染。Objective: To understand Pseudomonas aeruginosa infection and drug resistance for clinical rational use of antibiotics and provide scientific basis. Method: 219 strains of clinical isolated pseudomonas aeruginosa were collected in our hospital, its distribution, specimen source department and drug resistance were analyzed. Result: Pseudomanas aeruginosa was mainly distributed in the three veteran cadres wards ( 53.9% ), was mainly the separation of sputum specimens ( 91.3% ) ; drug resistance rate: cotrimoxazole ( 100% ), cefotaxime ( 83.94% ), gentamicin ( 53.42% ), ceftazidime ( 51.83% ) aztreonam ( 50.55% ), cephalosporins amoxicillin ( 50.27% ), ciprofloxacin ( 48.62% ), ievofloxacin ( 44.95% ), tobramyein ( 43.38% ), cefepime ( 42.66% ), amikacin ( 26.3% ), piperacillin / tazobactam ( 22.57% ), meropenem ( 16.9% ), imipenem ( 14.39% ) . Conclusion: Drug resistance of Pseudomonas aeruginosa mechanism is complex, should strengthen the monitoring of hospital drug resistant strains, to guide clinical rational use of antibiotics, take effective measures to prevent minimize Pseudomonas aeruginosa infection.
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