人参二醇磺酰化反应的研究  

Sulfonylation of Panaxadiol

作　　者：董成梅[1] 蒲洪[1] 邹澄[1] 赵庆[2] 张莲卿 胡建林[1] 杨淑达[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]云南中医学院中药学院,云南昆明650500

出　　处：《云南中医学院学报》2014年第2期17-20,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81160388);云南省科技厅与昆明医学院联合专项基金(2011FB245);云南省应用基础研究计划项目(2011FZ097);云南省天然药物药理重点实验室开放研究基金项目(2013G008)

摘　　要：目的研究三七中人参二醇的磺酰化反应,制备其衍生物。方法对人参二醇皂苷3位-羟基基团进行结构改造,通过与磺酰氯试剂反应制备其衍生物,并通过核磁对其结构进行鉴定。结果制备了4个人参二醇磺酰化衍生物。结论这4个化学物均为新化合物,这些化合物简便易得,为得到大量同类衍生物供活性筛选奠定了基础,由此为三七的深入研究与开发提供了新途径。Objective To study the sulfonylation of panaxadiol from Panax notoginseng. Methods A series of panaxadiol derivatives have been synthesized by Sulfuryl chloride with 3-hydroxy group of panaxadiol. The chemical structures of these derivatives were identified by NMR. Results Four derivatives were obtained. Conclusion These four derivatives were new compounds and can be obtained readily thus a large number of derivatives can be synthesized similarly for bioassay. This provides a new approach for the research and development of Panax notoginseng.

关 键 词：人参二醇 衍生物 磺酰化反应 合成 

分 类 号：R284.1[医药卫生—中药学]