布拉酵母菌对新生儿感染性肺炎继发腹泻的预防效果观察  

Effect of Antibiotics and Saccharomyces Boulardii Sachets in Prevention of Secondary Diarrhea in Neonates with Infectious Pneumonia

作　　者：汤明[1] 

机构地区：[1]湖北省仙桃市第一人民医院,湖北仙桃433000

出　　处：《儿科药学杂志》2014年第5期15-17,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察布拉酵母菌对新生儿感染性肺炎继发腹泻的预防效果。方法:选择2012年4月至2013年5月在我院就诊的新生儿感染性肺炎患儿146例,随机分为对照组和观察组各73例。两组均根据病情给予对症支持治疗,根据病原学检查结果选择合适抗生素治疗至肺炎痊愈;观察组在应用抗生素的同时口服布拉酵母菌每次125 mg,2次/天,直至肺炎痊愈;两组出现腹泻后均给予蒙脱石散治疗。观察两组腹泻发生情况及治疗疗程。结果:观察组腹泻发生率20.55%(15/73),低于对照组的46.58%(34/73);观察组出现腹泻时间为(5.78±1.52)d,晚于对照组的(3.27±1.34)d;观察组腹泻治疗72 h后腹泻次数为(5.27±1.48)次,少于对照组的(8.22±1.42)次;观察组腹泻持续时间(3.45±1.26)d,短于对照组的(5.05±1.73)d;观察组腹泻总疗程(4.23±1.77)d,短于对照组的(6.45±1.73)d。两组以上各项指标比较差异均有统计学意义(P均<0.05)。结论:布拉酵母菌对新生儿感染肺炎继发腹泻有良好的预防效果,可明显降低腹泻发生率,减轻腹泻症状,缩短腹泻病程。布拉酵母菌可用于预防新生儿抗生素相关性腹泻,安全有效,值得临床推广应用。Objective： To explore the preventive effects of antibiotics and saccharomyces boulardii sachets in treating secondary diarrhea in neonates with infectious pneumonia. Methods： One hundreds and forty-six patients with secondary diarrhea induced by neonatal infectious pneumonia in our hospital from April 2012 to May 2013 were randomly divided into an observation group （n = 73 ） and a control group （ n = 73 ）. Both of the two groups were given antibiotics and symptomatic supportive treatment. The observation group served Saccharomyces boulardii sachets additionally until the end of the course. Children in the two groups who were given montmorillonite powder when they had diarrhea. Results： There were fifteen cases of diarrhea in the observation group, and the incidence rate was 20.55% ; while there were thirty-four cases of diarrhea in the observation group, and the incidence rate was 46. 58% ; there had a significant difference between the two groups （P〈0.05）. The frequency of diarrhea in the observation group was significantly less than that in the control group after treatment for 72 hours. The duration and total treatment course of diarrhea in the observation group were significantly shorter than those in the control group. Conclusions： Antibiotics and saccharomyces boulardii sachets used in the prevention of secondary diarrhea induced by neonatal infectious pneumonia have good effect. It can effectively reduce diarrhea incidence rate and the degree of secondary diarrhea. It can be used to prevent the happening of the neonatal antibiotic associated diarrhea, and it is worth to clinical use and promotion.

关 键 词：布拉酵母菌 感染 肺炎 继发性腹泻 

分 类 号：R722.1[医药卫生—儿科]