硫酸头孢喹肟注射液的制备工艺研究  

Study on Cefquinome Sulfate Injection Preparation Process

作　　者：宋永军 李向阳 朱华伟 付旭东 

机构地区：[1]普莱柯生物工程股份有限公司,河南洛阳471000 [2]国家兽用药品工程技术研究中心,河南洛阳471003 [3]洛阳惠中兽药有限公司,河南洛阳471013 [4]石家庄动物疾病预防控制中心,河北石家庄050000

出　　处：《中国动物保健》2014年第5期11-14,共4页China Animal Health

摘　　要：通过对硫酸头孢喹肟注射液的辅料及分散工艺进行研究,确定了硫酸头孢喹肟注射液的制备工艺。选择油酸乙酯为载体并对其相容性进行了研究;确定了2.0%的硬脂酸铝作为助悬剂;确定了1.0%的卵磷脂作为表面活性剂;确定了高剪切分散后过高压均质机均质作为分散工艺,最终确定了硫酸头孢喹肟注射液的制备工艺。并将产品按照质量标准进行检测,结果符合规定。According to the study of materials and dispersion process to cefquinome sulfate injection,the prepa- ration of cefquinome sulfate injection is identified. Oleate is selected as a carrier and its compatihility is studied, 2.0% aluminum stearate as a suspending agent, 1.0% lecithin is determined as a surface active agent, ilomogenizing by high-pressure homogenizer after high shear dispersion as the dispersion process. Eventually, the preparation process to eefquinome sulfate injection determined and product quality conform to standard.

关 键 词：硫酸头孢喹肟 制备工艺 

分 类 号：S859.796[农业科学—临床兽医学]