高压臭氧自体血回输显著减轻干扰素治疗慢性丙型肝炎患者的不良反应  

Ozone-enriched autologous blood transfusion significantly reduce adverse reactions in chronic hepatitis C patients receiving interferon-α and ribavirin therapy

作　　者：夏冬丽[1] 马海林[1] 石绣江[1] 希尔娜依.阿不都黑力力 范晓棠[1] 何方平[1] 

机构地区：[1]新疆医科大学第一附属医院肝病科,乌鲁木齐市830054

出　　处：《实用肝脏病杂志》2014年第3期259-262,共4页Journal of Practical Hepatology

基　　金：新疆维吾尔自治区科技支撑项目(编号:201141137);国家自然科学基金资助项目(编号:81360138)

摘　　要：目的：探讨联合高压臭氧自体血回输治疗对干扰素治疗慢性丙型肝炎（CHC）患者临床疗效和不良反应的影响。方法105例 CHC 患者被分为对照组（52例，皮下注射干扰素和口服利巴韦林）和治疗组（53例，皮下注射干扰素和口服利巴韦林，联合应用高压臭氧自体血回输疗法，平均10～16次），疗程均为48周，随访24周，观察病毒学应答率和不良反应发生率。结果联合治疗组患者合并血清甘油三酯、高血压和糖尿病的发生率分别为28.3%、28.3%和28.3%，显著高于对照组的5.8%、7.7%和7.7%（P〈0.05），但两组患者在性别构成比、平均年龄、肝功能、HCV RNA 载量和肝硬化患者比率等方面差异无统计学意义；治疗前后两组肝功能指标变化的差异无统计学意义；治疗组患者发热、流感样症状和血红蛋白减低发生率分别为50.9%、35.8%和34.0%，显著低于对照组的73.1%、59.6%和55.8%（x2=5.5，P〈0.01；x2=5.9，P〈0.01和 x2=5.0，P〈0.01）；治疗组早期病毒学应答率、治疗结束时应答率和持续应答率分别为83.0%、83.0%和74.4%，与对照组相比无显著统计学差异（分别为88.5%、86.5%和76.3%）。结论尽管合并高代谢综合征，干扰素联合高压臭氧自体血回输治疗 CHC 患者病毒学应答率与对照组无显著性差异，但显著减少了不良反应发生率。高压臭氧自体血回输治疗可能成为减少干扰素不良反应的辅助疗法。Objective To study the effects of ozone-enriched autologous blood transfusion on the efficacy and adverse reactions in patients with chronic hepatitis C（CHC）receiving interferon-α and ribavirin therapy. Meth-ods One hundred and five CHC patients were divided into control group and treatment group;The patients in control group （n=52） were treated with subcutaneous injection of peginterferon-α and oral administration of rib-avirin,while the patients in treatment group （n=53） were treated with combinational therapy of interferon,and rib-avirin,and ozone-enriched autologous blood transfusion （an average of 10 to 16 times）. The regimen lasted for 48 weeks with a 24 week-posttreatment of follow-up. The virologic response rates and adverse reactions were observed. Results The incidence rates of serum high triglycerides levels,hypertension and diabetes in patients of treatment group were 28.3%,28.3% and 28.3%,respectively,significantly higher than those in the control patients（5.8%,7.7%and 7.7%,respectively,P〈0.05）;No significant differences as respect to gender,average age,liver function tests,HCV RNA load and percentage of cirrhosis were observed between the two groups;The incidence rates of fever, flu-like symptoms and reduction of hemoglobin in patients of the treatment group （50.9%,35.8% and 34.0%,respectively） were significantly lower than those in the control patients （73.1%,x2=5.5,P〈0.01;59.6% x2=5.9,P〈0.01 and 55.8%, x2=5.0,P〈0.05）;The rates of early virologic response,virologic response at end of treatment and sustained virologic response in patients in the treatment group（83.0%, 83.0% and 74.4%,respectively） were not significant-ly different from those （88.5%,86.5% and 76.3%, respectively） in the control patients. Conclusions Although some patients having metabolic syndrome, the virologic response rate in patients receiving in-terferon-α and ozone-enriched autologous blood transfusion is very high,with reduced adverse reac-tions. Ozone-enriched autologous blood tr

关 键 词：慢性丙型肝炎 高压臭氧自体血回输 干扰素 不良反应 

分 类 号：R512.63[医药卫生—内科学]