青黄散及健脾补肾方药联合西药治疗骨髓增生异常综合征107例临床观察  

Clinical Observation on Qinghuang Powder,Spleen-Strengthening Kidney-Supplementing Formulas and Western Medicine for 107 Cases of Myelodysplastic Syndrome

作　　者：周庆兵[1] 王洪志[1] 杨秀鹏[1] 郭小青[1] 杨晓红[1] 许勇钢[1] 胡晓梅[1] 麻柔[1] 

机构地区：[1]中国中医科学院西苑医院,北京市海淀区西苑操场1号100091

出　　处：《中医杂志》2014年第10期838-841,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30973812;30973903)

摘　　要：目的观察青黄散加补肾健脾中药联合西药治疗骨髓增生异常综合征(MDS)的临床疗效。方法收集107例MDS患者,给予青黄散、健脾补肾汤药及雄性激素,治疗时间为3个月,检测治疗前后患者外周血白细胞(WBC)计数、血红蛋白(Hb)含量、血小板(PLT)计数,并评价血液学指标疗效、不同分型疗效、不同国际预后积分系统(IPSS)危险度分层疗效、不同遗传学分组疗效。结果 107例患者治疗前后外周血细胞计数比较,WBC、PLT治疗前后差异无统计学意义(P>0.05),Hb含量治疗前后差异有统计学意义(P<0.01)。Hb与WBC疗效比较、Hb与PLT疗效比较差异均有统计学意义(P<0.01),而WBC与PLT疗效比较差异无统计学意义(P>0.05)。两组患者不同分型疗效比较、不同IPSS危险度分层疗效比较、不同遗传学分组疗效比较差异均无统计学意义(P>0.05)。结论青黄散加健脾补肾中药联合西药综合治疗MDS具有确切的临床疗效,主要对红系起作用,疗效与分型、IPSS危险度分层及遗传学分组无明显相关性。Objective To observe the efficacy of Qinghuang Powder, Spleen-Strengthening Kidney-Supplementing Formula （SKF） and western medicine for myelodysplastic syndrome （MDS）. Methods Totally 107 cases of outpatient with MDS were included and treated with Qinghuang Powder, SKF and androgens. The treatment lasted for 3 months. The white blood cell （WBC） count, hemoglobin （Hb） level and platelet （PLT） count were detected before and after treatment. The efficacy of blood cells, types, International Prognostic Scoring System （IPSS） and genetic groups were evaluated. Results There was no significant difference between before and after treatment in WBC and PLT （ P 〉 0.05 ）. There was a significant difference between before and after treatment in Hb （ P 〈 0. 05 ）. There was a significant difference between the efficacy of Hb and WBC （ P 〈 0. 01 ）. There was a significant difference between the efficacy of Hb and PLT （P 〈 0.01 ）. There was no significant difference between the efficacy of WBC and PLT （ P 〉 0.05 ）. There was no significant difference in the efficacy of types, IPSS and genetic groups （P 〉 0.05 ）. Conclusion The combo therapy of Qinghuang Powder, SKF and western medicine is effective for MDS and mainly affects erythroid cells. The efficacy is not obviously correlated with types, IPSS and genetic groups.

关 键 词：骨髓增生异常综合征 青黄散 健脾补肾 中西结合治疗 

分 类 号：R551.3[医药卫生—血液循环系统疾病]