微柱凝胶技术检测IgG抗-A/B效价与新生儿溶血病相关性  

The correlation between IgG anti-A/B titers by the gel test and hemolytic disease of the newborn

作　　者：张敏[1] 芦慧霞[1] 辛琪[1] 梁路石 

机构地区：[1]东南大学附属中大医院输血科,江苏南京210009

出　　处：《中国输血杂志》2014年第4期402-404,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探讨微柱凝胶技术检测孕妇IgG抗-A／B效价与新生儿溶血病的相关性。方法采用微柱凝胶技术检测443例ABO血型不合的O型孕妇IgG抗-A／B效价，观察抗体分布情况及抗体效价与新生儿溶血病相关性。结果443名孕妇所产新生儿中28例发生新生儿溶血病，发病率为6．32％。抗体效价≤128的孕妇所产新生儿均未发生新生儿溶血病。新生儿溶血病患儿母亲抗体效价范围256—2048，发病率有随抗体效价升高而上升的趋势。IgG抗-A、IgG抗-B效价为512时发病率明显升高，P〈0．05。IgG抗-AB效价为256时发病率明显升高，P〈0．05。此外，新生儿溶血病发病情况与妊娠次数无明显相关性，初次、再次怀孕血型抗体效价也无相关性，第1胎也可发病。结论新生儿溶血病发病率随着孕妇抗体效价增高而增加，孕妇IgG抗-A／B效价≥256时有发生ABOHDN的可能性，应引起临床医生重视，孕妇IgG抗-A／B效价≥512的孕妇所产新生儿发生ABOHDN的可能性较大。Objective To explore the correlation between IgG anti-A/B titers by the gel test and hemolytic disease of the newborn. Methods Detect IgG anti-A/B titers of 443 blood group O pregnant who is ABO-incompatible by the gel test. Observe the distribution of IgG anti-A/B titers among them and to explore the correlation between IgG anti-A/B titers and hemolytic disease of the newborn. Results In general,28 of 443 births are ABO hemolytic disease. Morbidity of ABO hemolytic disease in the newborn is 6.32%. None of the newborns with maternal IgG anti-A./B titers ≤28 have ABO hemolytic disease. All of the hemolytic newborn infants with maternal IgG anti-A/B titers between 256 and 2 048. Morbidity rise up with the increasing of IgG anti-A/B titers. The incidence of the disease was increased significantly when IgG anti-AZB titers of maternal ≥ 512 or IgG anti-AB titers ≥256, P 〈 0. 05. There is no significant correlation between morbidity of ABO hemolytic disease and the number of pregnancies. There is no correlation between IgG anti-A/B titers and the number of pregnancies. It is possible that ABO hemolytic disease could be found in the first newborn of the female. Conclusion Morbidity of ABO hemolytic disease rise up with the increasing of IgG anti-A/B titers. It is possible that newborn infants with maternal IgG anti-A/B titers i〉256 could lead to ABO hemolytic disease. Doctors should pay attention to them. Newborns with maternal IgG anti-A/B titers ≥512 have a greater chance for ABO hemolytic disease.

关 键 词：微柱凝胶技术 IgG抗-A B 新生儿溶血病 

分 类 号：R457.1[医药卫生—治疗学]