T-SPOT.TB试验在活动性结核诊断中的价值及其影响因素分析  

Diagnosis Value and Its Influencing Factors of T-SPOT.TB for Active Tuberculosis

作　　者：卢青纯 唐小燕[1] 熊恬园 黄骥翀[2] 杨旻[1] 童翔[1] 范红[1] 

机构地区：[1]四川大学华暇医院呼吸内科,成都610041 [2]四川大学华西临床医学院,成都610041

出　　处：《中国循证医学杂志》2014年第5期522-526,共5页Chinese Journal of Evidence-based Medicine

基　　金：四川省科技厅科技支撑计划资助项目(编号:2012JY0013)

摘　　要：目的探讨T-SPOT.TB试验在活动性结核临床诊断中的价值及其影响因素。方法对2010年7月至2012年11月就诊于四川大学华西医院的289例疑似肺结核患者行T-SPOT.TB试验,评价应用T-SPOT.TB试验诊断活动性结核的价值。结果根据诊断标准,最终纳入结核感染组84例及对照组156例。T-SPOT.TB试验诊断活动性结核的敏感度为83.3%,特异度为80.1%。单因素及多因素分析结果表明,患者年龄、性别等基础情况及免疫抑制状态、恶性肿瘤等基础疾病均不是试验结果的影响因素。结论 T-SPOT.TB试验对诊断活动性结核具有较高的敏感度及特异度,对疑似结核患者的诊断具有重要参考价值。Objective To explore the value of T-SPOT.TB test in the diagnosis of active tuberculosis and its influencing factors. Methods From July 2010 to November 2012, a total of 289 suspected active tuberculosis patients were enrolled in the study and underwent T-SPOT.TB test. All the patients enrolled were from West China Hospital of Sichuan University. The diagnostic value of T-SPOT.TB applied in determining active tuberculosis was then evaluated. Results According to the diagnostic criteria, 84 patients diagnosed with active tuberculosis were eligible for analysis and enrolled as a tuberculosis group, and 156 patients were enrolled as a control group. The sensitivity of T-SPOT.TB test was 83.3%, while the specificity was 80.1%. Both univariate and multivariate analyses showed the characteristics of patients such as general conditions （eg. age, sex） and basic diseases （eg. immunosuppression condition, malignant tumour） were not the risk factors of false-positive or false-negative result of T-SPOT.TB. Conclusion T-SPOT.TB test for the diagnosis of active tuberculosis has high sensitivity and specificity, with important value referred for diagnosing suspected active tuberculosis patients.

关 键 词：活动性结核 T-SPOT TB 危险因素 诊断 

分 类 号：R52[医药卫生—内科学]