近视与开角型青光眼关系的Meta分析  

Association between Myopia and Open-angle Glaucoma: A Meta-Analysis

作　　者：熊期[1,2] 曾宪涛[3] 蔡小军[2] 李志良[4] 李朝辉[2] 李胜[1,5] 

机构地区：[1]武汉大学第二临床学院,武汉430071 [2]武汉大学中南医院眼科,武汉430071 [3]湖北医药学院附属太和医院循证医学中心,湖北十堰442000 [4]华中科技大学同济医学院附属协和医院骨科,武汉430022 [5]武汉大学中南医院泌尿外科,武汉430071

出　　处：《中国循证医学杂志》2014年第5期618-624,共7页Chinese Journal of Evidence-based Medicine

基　　金：湖北省科技厅面上项目(编号:2012FFB04324)

摘　　要：目的系统评价近视与开角型青光眼（OGA）的相关性。方法计算机检索PubMed、EMbase、WanFang Data、VIP和CNKI数据库，收集国内外2000年1月～2013年5月公开发表的近视与OGA相关性的观察性研究。由2位研究者按照纳入与排除标准独立筛选文献、提取资料并评价纳入研究的方法学质量后，采用Stata 12.0软件进行Meta分析。结果最终纳入11个横断面研究，共45996例患者。Meta分析结果显示：近视会增加罹患OGA的风险[OR=1.91，95％CI（1.53，2.38）]。按照近视程度行亚组分析，结果显示低度近视（〉-3.00D）与中、高度近视（≤-3.00 D）发生OGA的风险分别为1.52倍[OR=1.52，95％CI（1.23，1.88）]和2.41倍[OR=2.41，95％CI（1.91，3.03）]。结论近视会增加OGA的发病风险。Objective To systematically review the association between myopia and open-angle glaucoma （OAG）. Methods Foreign and domestic articles published from January 2000 to May 2013 were searched in PubMed, EMbase, WanFang Data, VIP and CNKI for observational studies on the association between myopia and OAG. According to the inclusion and exclusion criteria, the studies were screened, the data were extracted, and the method quality of included studies was assessed. Then meta-analysis was performed using Stata 12.0 software. Results Eleven cross-sectional studies including 45 996 participants were finally included. The results of meta-analysis showed that, myopia increased the risk of OAG. Besides, the results of subgroup analysis by the severity of myopia showed that, low-degree myopia （more than -3.00 D） increased 1.52 times the risk （OR=1.52, 95%CI 1.23 to 1.88） while middle/high-degree myopia （no more than -3.00 D） increased 2.41 times （OR=2.41, 95%CI 1.91 to 3.03）. Conclusion Individuals with myopia have increased risk of OAG

关 键 词：近视 开角型青光眼 系统评价 META分析 横断面研究 

分 类 号：R755[医药卫生—皮肤病学与性病学]