中国人群HLA-B基因多态性与HIV关联性的Meta分析  

Association of HLA-B Gene Polymorphism and HIV Infection and Progression in China:A Meta-Analysis

作　　者：谢彦昕[1] 朱一[1] 吴建茹[1] 王蓓[1] 

机构地区：[1]东南大学公共卫生学院环境医学工程教育部重点实验室,南京210009

出　　处：《循证医学》2014年第2期87-93,共7页The Journal of Evidence-Based Medicine

基　　金：国家自然科学基金资助项目(30872156)

摘　　要：目的系统评价中国人群HLA-B基因多态性与HIV易感性及疾病进程的关系。方法全面检索查找已发表的相关病例对照研究及横断面研究,并追溯其参考文献,按纳入和排除标准进行文献筛选、资料提取及质量评价,使用RevMan 4.2及SAS 9.1.3软件进行统计分析。结果共纳入11篇文献。6篇为HLA-B基因与HIV疾病进程相关性研究,Meta分析结果显示,HLA-B*27、HLA-B*51和HLA-B*58为HIV/AIDS病程进展的保护性基因,合并比值比分别为0.49、0.61和0.65。HLA-B*35为HIV/AIDS病程进展的危险基因,合并比值比为1.87。5篇为HLA-B基因与HIV易感性的关联性研究,Meta分析结果显示,HLA-B*37和HLA-B*46为HIV感染的易感性基因,合并比值比分别为1.62和1.19。HLA-B*39为HIV感染保护性基因,合并比值比为0.67。结论 HLA-B*27、HLA-B*51和HLA-B*58可能延缓而HLA-B*35可能加速中国人群HIV感染后的疾病进程;HLA-B*39可能降低而HLA-B*37和HLA-B*46可能增高中国人群对HIV感染的易感性。Objective To evaluate the association between gene of HLA-B and HIV infection and disease progression in Chinese population. Methods Electronic searches were conducted roundly to find the case-control studies and cross-sectional studies on the association between HLA-B gene polymorphism and HIV infection or disease course. References of relevant studies were also retrieved. The references was screened with the inclusion and exclusion criteria, and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 4.2 and SAS 9.1.3. Results 11 studies were included lastly. 6 studies were about the association between gene of HLA-B and disease progression in Chinese HIV infected population , meta-analysis results revealed that the pooled OR of HLA-B＊27, HLA-B＊51, and HLA-B＊58 were 0.49, 0.61 and 0.65 respectively, and they acted as the protective genes in the HIV/AIDS progression. HLA-B＊35（pooled OR=1.87） was the risk gene in the HIV/AIDS progression. 5 studies were about the association between gene of HLA-B and HIV infection in Chinese population, meta-analysis results revealed that the pooled OR of HLA-B＊37 and HLA-B＊46 were 1.62 and 1.19, and they acted as the susceptible genes in HIV infection. HLA-B＊39（pooled OR=0.67） was the protective gene in HIV infection. Conclusions HLA-B＊27, HLA-B＊51 and HLA-B＊58 may act as the protective genes in HIV infected disease progression , and HLA-B＊35 may act as the susceptible gene in HIV infected disease progression;HLA-B＊39 may act as the protective gene in HIV infection. HLA-B＊37 and HLA-B＊46 may act as the susceptible genes in HIV infection.

关 键 词：HIV易感性 HIV疾病进程 HLA-B等位基因 META分析 

分 类 号：R512.91[医药卫生—内科学]