天然免疫细胞在1型糖尿病中的作用  

Role of innate immune cells in type 1 diabetes mellitus

作　　者：陈晔[1] 李艳玲[1] 王坚[1] 

机构地区：[1]南京军区南京总医院内分泌科,210002

出　　处：《国际内分泌代谢杂志》2014年第3期184-187,共4页International Journal of Endocrinology and Metabolism

摘　　要：1型糖尿病（T1DM）是一种复杂的自身免疫性疾病,主要是由T、B细胞破坏胰岛β细胞所致.虽然病因不明,但最终一系列天然免疫细胞及特异性免疫细胞相互作用,导致胰岛β细胞损伤和T1DM的发生.对动物模型和T1DM患者的研究发现,单核/巨噬细胞、自然杀伤细胞、自然杀伤T细胞、树突状细胞和淋巴细胞相互作用可影响T1DM的发生、发展.因此,研究天然免疫细胞在T1DM发生、发展中的作用,可能为防治T1DM提供新的方向.Type 1 diabetes mellitus （T1DM） is a complex autoimmune disease resulting from the specific destruction of islet β cells by T cells and B cells. The pathogenesis of T1DM remains elusive. Ultimately, the interplay between natural immune cells and specific immune cells triggers the destruction of β cells and onset of T1DM. The interaction of macrophage, natural kill cell, natural killer T cells and dendritic cells induced by susceptible gene and environmental factors with antigen-specific lymphocytes has been implicated in the development of autoimmune diabetes in animal models and patients with T1DM.Studies of the role of natural immune cells in initiating T1DM may provide innovative clinical approaches for prevention or treatment of T1DM

关 键 词：1型糖尿病 天然免疫细胞 自身免疫 

分 类 号：R392[医药卫生—免疫学]