206例胸闷患者病因分析及辅酶Q10治疗效果评价  

Etiology and treatment effect by coenzyme Q10 of 206 patients with chest tightness

作　　者：杨硕[1] 贺立群[2] 雷健[2] 罗光伟[1] 万军[1] 黄小龙[1] 李佐民[2] 昌薇[2] 柯于鹤[2] 

机构地区：[1]武汉市第一医院呼吸科,武汉430081 [2]武汉市第一医院心血管内科,武汉430081

出　　处：《中国处方药》2014年第5期19-20,共2页Journal of China Prescription Drug

基　　金：武汉市卫生局资助课题(2010WX10C05)

摘　　要：目的：探讨胸闷患者的常见病因，并评价辅酶Q10对缓解胸闷症状治疗效果。方法选择2010年9月～2013年1月间住院的无心肺病史胸闷患者206例,随机分为治疗组和对照组，在常规治疗基础上，对照组患者口服维生素C片、治疗组口服辅酶Q10治疗。对患者临床表现及检查结果进行分析。结果胸闷患者的病因主要有：冠脉慢血流现象、慢性阻塞性肺疾病、支气管哮喘、冠心病、气胸、急性上呼吸道感染、胸腔积液、肺炎、心律失常、肺癌、心肌炎等。治疗组胸闷症状明显改善（Z＝2.197，P＝0.028）。结论无心肺病史胸闷患者发病主要原因为冠脉慢血流现象及慢性阻塞性肺疾病，在诊断明确前辅酶Q10有助于安全缓解症状。Objective Investigate the etiology of patients with chest tightness, and evaluation the effect of coenzyme Q10 on chest tightness. Methods Single blind placebo study was adopted in this study.206 cases of hospitalized patients with chest tightness were selected in Wuhan No.1 Hospital without history of heart or lung diseases from 2010 September to 2013 January, and randomly divided into treatment group and control group. On the basis of routine treatment, patients in the control group gave oral Vitamin C Tablets, treatment group with oral coenzyme Q10 therapy. The clinical manifestations and examination results were recorded. Results The etiology of these patients were：coronary slow flow phenomenon, chronic obstructive pulmonary disease, asthma, coronary heart disease, acute upper respiratory tract infection, pneumothorax, pleural effusion, pneumonia, lung cancer, cardiac arrhythmias, myocarditis. In the treatment group chest symptoms were alleviated significantly（Z=2.197, P=0.028）. Conclusion In patients without history of heart or lung diseases,chest tightness was caused by coronary slow flow phenomenon and chronic obstructive pulmonary disease mainly. Before diagnosis it can relieve the symptoms and be safety to oral coenzyme Q10.

关 键 词：胸闷 辅酶Q10 冠脉慢血流现象 

分 类 号：R441[医药卫生—诊断学]