纳米金在比色传感分析中的应用  

Application of Gold Nanoparticles in Colorimetric Assay

作　　者：沈丽[1] 

机构地区：[1]北京物资学院物流学院,北京101149

出　　处：《材料导报》2014年第9期35-41,共7页Materials Reports

基　　金：北京市教育委员会科技计划面上项目(SQKM201210037002);国家自然科学基金(20905009);北京市物流系统与技术重点实验室专项基金

摘　　要：纳米金具有良好的生物相容性,易于进行表面修饰,且具有独特的光学性能。在紫外可见光谱中,纳米金所产生的吸收峰的位置与纳米金粒子之间的距离、颗粒(或聚集态)大小和形状有关,吸收峰的强度与溶液中纳米金的浓度线性相关。因此,纳米金在开发比色传感器方面具有独特的优势。评述了近年来生物大分子-纳米金复合物、有机小分子-纳米金复合物、未修饰的纳米金、纳米金生长在比色传感分析中的应用以及固体纳米金比色传感器的研究进展,结合实例阐述了纳米金比色传感分析的机理,并对其优缺点进行了总结,对未来的发展方向进行了展望。Gold nanoparticles （AuNPs） which are easy to be modified possess good biocompatibility and unique optical properties.Studies show that the maximum of the absorption band from AuNP surface plasmon is related to the particles＇ size and shape,distance between AuNPs and the aggregation states of the particles,while the intensity of the absorbance band has quantitative relationship with the concentration of the AuNPs in the solutions.Therefore,AuNPs have been widely used in the development of colorimetric sensor.The application of biomacromolecule-AuNP complex,organic molecule-AuNP complex and unmodified AuNPs in colorimetric assay,the colorimetric assay based on the growth of AuNPs and the development of AuNP colorimetric paper are reviewed.In addition,the colorimetric sensing mechanism of AuNPs is elaborated combined with examples.The advantages and disadvantages are summarized and the future outlook is also discussed.

关 键 词：纳米金 比色传感分析 生物大分子-纳米金复合物 有机小分子-纳米金复合物 纳米金生长 比色试纸 

分 类 号：O657.32[理学—分析化学]