滤泡辅助性T细胞在免疫相关性血液病中的研究进展  

Research of follicular helper T cells in immune-related blood diseases

作　　者：张洋[1] 瞿文[1] 邵宗鸿[1] 

机构地区：[1]天津医科大学总医院血液科,300052

出　　处：《国际免疫学杂志》2014年第3期211-214,共4页International Journal of Immunology

摘　　要：T细胞亚群异常是导致免疫相关性血液病发病的重要因素，其发病机制与Thl／Th2、Thl7细胞、调节性T细胞（Treg）等辅助性T细胞异常有关。滤泡辅助性T细胞（Tfh）作为新近发现的辅助性T细胞具有辅助B细胞产生抗体的作用，其产生、分化和功能均不同于以往的Thl、Th2和Thl7等CD4＋T细胞。Tfh细胞及其相关分子的数量和／或功能异常在免疫相关性血液病的发病中发挥重要作用，有望成为其新的治疗靶点。The abnormal quantity and functions of T cell subsets contributes to the pathogenesis of immune-related blood diseases. The production of autoantibodies in these diseases was related to abnormal quantity and functions of B lymphocytes, which in turn are caused by the inhibition of regulatory T cells （Treg） , T helper （Th） 1, and activated Th2 and Thl7 cells. T follicular helper cells （Tfh cells） are a newly defined effeetor T cell subset and the true helper cells for antibody responses. The production, differentiation and function of Tfh cells are different from that of other CD4＋ T cells, such as Thl, Th2 and Thl7 cells. Tfh cells play an important role in immune-related blood disease. It is expected Tfh cells might be a new therapeutic target for immune-related blood disease.

关 键 词：免疫相关性血液病 滤泡辅助性T细胞 

分 类 号：R552[医药卫生—血液循环系统疾病]