Calf Thymus DNA Intercalation by Anionic Ru（Ⅲ） Complexes Containing Tridentate Schiff Bases Derived from 5-X-Substituted Salicyladehyde and 2-Aminophenol  

作　　者：Emlra Kahrowc Adnan Zahirovic Emir Turkusic 

机构地区：[1]Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo 71000, Bosnia and Herzegovina

出　　处：《Journal of Chemistry and Chemical Engineering》2014年第4期335-343,共9页化学与化工（英文版）

摘　　要：Sodium bis[N-2-oxyphenyl-5-substituted-salicylideneiminato-ONO]ruthenate（Ⅲ） hemitriethylamine compounds of general formula Na[Ru（N-R-5-X-salim）2]＇0.5Et3N, where, R = C6H40, X = El, Br, NO2, salim = salicylideneiminato, Et3N triethylamine, were synthesized and characterized on the basis of elemental analysis, MALDI-TOF （matrix-assisted laser desorption/ionization/time-of-flight） mass spectra, IH NMR （nuclear magnetic resonance）, electronic spectra and cyclic voltammograms. Ru（Ⅲ） is chelated with two O2N anionic tridentate Schiff bases derived from 5-X-salicyladehyde and 2-aminophenol. Spectroscopic titrations of the Ru（Ⅲ） compounds with CT DNA （calf thymus DNA） in the LMCT （ligand metal charge transfer） region have shown moderate intercalation properties of compounds with binding constants KD = 2.06-3.85 × 104 Ml. Electrochemical evidence of intercalative mode of binding is based on the decrease of current and shift of anodic and cathodic peaks towards higher values of potential with IxL-increment of CT DNA in Ru（Ⅲ） compound solution.

关 键 词：RUTHENIUM Schiff bases salicylideneimine CT DNA intercalation. 

分 类 号：O625.632[理学—有机化学] Q523[理学—化学]