壳聚糖成膜剂的杀菌效果与毒理学研究  

Study on germicidal efficacy and toxicology of chitosan film formers

作　　者：王余华[1] 王晓[1] 刘科亮[1] 

机构地区：[1]四川省疾病预防控制中心,四川成都610041

出　　处：《现代预防医学》2014年第10期1842-1843,共2页Modern Preventive Medicine

摘　　要：目的了解壳聚糖成膜剂的杀菌效果及其毒性。方法悬液定量杀菌试验和动物毒性试验。结果该样品作用大肠杆菌,金黄色葡萄球菌2 min,杀灭对数值>5.00,作用白色念珠菌2 min,杀灭对数值>4.00,稳定性试验结果证明,该产品稳定性好,毒性试验结果表明,对皮肤无刺激。结论壳聚糖成膜剂具有良好的杀灭微生物性能,毒性低,稳定性好,可广泛用于皮肤、伤口等消毒。Objective This study was to learn the germicidal efficacy and toxicology of chitosan film formers. Methods Suspension quantitative germicidal test and animal toxicity test were conducted. Results The killing logarithm value of Escherichia coli and Staphylococcus aureus exposed to the solution for 2 min was 〉5.00 in average. That of Candida albicans with the same exposure was 〉4.00 in average. The product was stable and not irritating to skin. Conclusion The chitosan film formers are recommended to be widely used in skin and wound disinfection because of its good germicidal efficacy and low toxicity.

关 键 词：壳聚糖 杀菌作用 毒性 

分 类 号：R187[医药卫生—流行病学]