不同品质白酒对大鼠慢性酒精性脑损伤的影响  

Chronic Effect of Luzhou-flavor Liquor in Different Quality on Alcoholic Brain Injuries in Rats

作　　者：叶正茂[1] 陈蕊[1] 鲁蕾[1] 范雪佳[1] 饶家权[2] 杜礼泉[2] 裴晓方[1] 许欣[1] 

机构地区：[1]四川大学华西公共卫生学院(华西第四医院),四川成都610041 [2]四川省绵阳市丰谷酒业有限责任公司,四川绵阳621000

出　　处：《现代预防医学》2014年第10期1856-1858,共3页Modern Preventive Medicine

摘　　要：目的比较两种不同品质浓香型白酒对大鼠慢性酒精性脑损伤的影响。方法将55只清洁级SD雄性大鼠,随机分为空白对照组,乙醇对照组,①号酒样组,②号酒样组。以48.0%乙醇溶液为对照,分别每天经口给予SD大鼠两种不同品质白酒,12周后经股动脉取血测定血清中特异性神经烯醇化酶(NSE)含量,取血后颈椎脱臼处死动物取脑测定脑组织匀浆中总超氧化物歧化酶(T-SOD)、丙二醛(MDA)含量,并进行大脑病理组织学检查。结果连续灌胃12周后,脑组织病理组织学切片结果显示,①号酒样组的病变程度轻于②号酒样组。与②号酒样组相比,①号酒样组SOD含量较高(P<0.01),MDA含量较低(P<0.01)。结论①号酒样所致大鼠慢性酒精性脑损伤小于②号酒样,提示可能与白酒所含杂醇油、乙醛对脑组织的损伤有关。Objective This study was to compare the chronic effect of two kinds of Luzhou-flavor liquor on alcoholic brain injuries in rats. Methods 55 SD male rats of clean grade were randomly divided into blank control group, the ethanol control group, liquor no. 1 group and liquor no. 2 group. Ethanol solution of 48.0% （v/v） was used for the ethanol control group. SD rats were orally administered with the two kinds of liquor daily for 12 weeks. Blood samples were then taken from the femoral artery of rats to measure the level of neural specific enolase （NSE）. After that, the animals were sacrificed by cervical dislocation to take the brains for measuring the total superoxide dismutase （T-SOD） and the content of malondialdehyde （MDA）, and for the brain histopathological examination. Results Compared to the group treated with liquor No.2, the group of liquor No.1 displayed less pathological damage. Meanwhile, the level of SOD increased （P〈0.01） and the content of MDA reduced （P〈0.01） in the group treated by liquor No.1. Conclusion The Luzhou-flavor liquor No. 1 caused less alcoholic brain damage in rats, suggesting that fusel oil and aldehyde etc. in liquor are the factors causing brain damage.

关 键 词：脑损伤 NSE SOD MDA 

分 类 号：R319[医药卫生—基础医学]