菏泽市2012年手足口病实验室检测病原学结果分析  

Etiological analysis of the laboratorial tests of hand-foot-and-mouth disease in Heze City in 2012

作　　者：李晓寒[1] 刘芳[1] 刘倩[1] 刘启林[1] 陈仲全[1] 

机构地区：[1]菏泽市疾病预防控制中心,山东菏泽274000

出　　处：《现代预防医学》2014年第10期1899-1900,1908,共3页Modern Preventive Medicine

摘　　要：目的明确2012年菏泽市手足口病（HFMD）实验室检测病原学及分布特点。方法采集临床诊断为手足口病病例粪便或咽拭子标本，Real—Time PCR对肠道病毒EV71型、CA16型进行检测，并对检测结果进行分析。结果396份临床标本中核酸检测阳性380份，检出率95．96％。阳性病例分布在各个县区，但EV71、CA16分布各有差异；不同月份发病率不同，3—5月仍为高发期；1～3岁仍是HFMD的高发年龄段，EV71依然是引发重症病例的主要病原。结论2012年菏泽市HFMD病原以EV71为主，发病分布在不同区域、年龄、月份有差异。Objective The study aimed to establish the etiology and distribution characteristics of laboratorial tests of hand-foot- and-mouth disease （HFMD） in Heze City in 2012. Methods Feces and throat swab specimens of cases clinically diagnosed as having HFMD were collected. Real-time PCR was used to detect the presence of Enterovirus 71 （EV71） and Coxsackievirus A16 （CA16） in the specimen. Results Among the 396 clinical specimens, 380 were tested viral nucleic acids positive, with a positive rate of 95.96%. The positive cases were equally distributed in different counties, but the distributions of EV71 and CA16 were distinct. Incidence of the infections varied by month and continued to peak during March to May. Age 1 to 3 was still the high-risk age group of HFMD, and EV71 had remained to be the main pathogen for severe cases. Conclusion EV71 was the main HFMD-causing pathogen in Heze City in 2012. The distribution of infections varied in different areas, ages and months.

关 键 词：手足口病 EV71 CA16 

分 类 号：R183.7[医药卫生—流行病学]