环境低硒与农村老年人群血压关系的初步研究  

Preliminarty study on the relationship between environmental low selenium exposure and blood pressure in rural elderly Chinese

作　　者：苏丽琴[1] 程义斌[1] 梁超轲[1] 马凤[1] 陈晨[1] 刘静怡[1] 李平[2] 金银龙[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]四川省疾病预防控制中心

出　　处：《中华地方病学杂志》2014年第3期335-338,共4页Chinese Journal of Endemiology

基　　金：美国NIH项目（R01AG019181）

摘　　要：目的探讨环境低硒与我国农村老年人群血压的相关性。方法从环境低硒地区和适宜硒地区分别抽取≥65周岁的农村老年人群各500名，开展流行病学调查和人体学测量（包括血压测量）；收集手指甲样品，采用2，3．二氨基萘荧光法检测硒含量。结果低硒地区人群指甲硒含量为（0．211±0．057）μg／g，适宜硒地区人群指甲硒含量为（0．434±0．136）μg／g，二者比较，差异有统计学意义（t=33．87，P〈0．05）。调整性别、年龄、吸烟、饮酒、体质指数（BMI）、教育程度后，总人群指甲硒含量与收缩压和舒张压均呈显著正相关（r值分别为0．231、0．188，P均〈0．05），但低硒地区人群和适宜硒地区人群分别独立分析均未发现明显相关性（P均〉0．05）。适宜硒地区人群高血压检出率（68.4％，342／500）显著高于低硒地区人群（41．2％，206／500），二者比较，差异有统计学意义（χ2=74．67，P〈0．05）。按照指甲硒水平五分位数将观察对象划分成5组后，未发现5组间高血压检出率的差异有统计学意义（P均〉0．05）。结论环境低硒暴露可能与老年人血压存在关联，但尚需大规模纵向人群研究来进行论证。Objective To preliminarily explore the relationship between environmental low selenium exposure and blood pressure in rural elderly Chinese. Methods Respectively 500 subjects aged 65 or older were recruited from environmental low and optimal selenium rural areas. Questionnaire survey and physical measurement including blood pressure, were carried out. Finger nail samples were collected and the trace amount of selenium was detected with 2, 3-diaminonaphthalenet fluorometric determination method. Results Finger nail selenium level [ （0.211 ± 0.057 ）μg/g ] of subjects in low selenium areas was significantly lower than that [ （0.431 ±0.136） μg/g ] of subjects in optimal selenium areas （t = 33.87, P 〈 0.05）. Systolic blood pressure （SBP） and diastolic blood pressure（DBP） were positively associated with finger nail selenium levels in overall population（rSBP = 0.231 ,rDBP = 0.188, all P 〈 0.05）, but no such association was observed in population of optimal selenium areas or low selenium areas. The detection rate of hypertension [ 68.4% （342/500）] in optimal selenium areas was significantly higher than that [ 41.2% （206/500） ] of low selenium areas （χ2 = 74.672, P 〈 0.05）, but no significant difference was observed among 5 groups of subjects in different selenium quintiles（all P 〉 0.05）. Conclusions Low environmental selenium exposure may be associated with blood pressure in elderly population. Large-scale and longitudinal population studies are needed to verify the possible association.

关 键 词：硒 环境暴露 血压 老年人群 

分 类 号：R544.1[医药卫生—心血管疾病]