酸酐酯化法制备人参二醇衍生物  

Preparation of Panaxadiol Derivat ives with Acid Anhydrides

作　　者：董成梅[1] 蒲洪[1] 邹澄[1] 赵庆[2] 胡建林[1] 杨淑达[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室 [2]云南中医学院中药学院,云南昆明650500

出　　处：《昆明医科大学学报》2014年第6期4-8,28,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81160388);云南省科技厅-昆明医科大学联合专项基金资助项目(2011FB245);云南省应用基础研究基金资助项目(2011FZ097)

摘　　要：目的设计合成人参二醇衍生物.方法对人参二醇皂苷3位-羟基基团进行结构改造,通过一系列的酰化反应制备其衍生物,并通过核磁对其结构进行鉴定.结果制备了6个人参二醇衍生物,其中5个化学物为新化合物.结论这些化合物简便易得,因而为得到大量同类衍生物供活性筛选奠定了基础,为三七的深入研究与开发提供了新途径.Objective To design and synthesize panaxadiol derivatives.Methods A series of panaxadiol derivatives were synthesized with simple acylation of 3-hydroxy group of panaxadiol.The chemical structures of these derivatives were identified by NMR.Results Six derivatives were obtained and five of them were new compounds.Conclusions These derivatives can be obtained readily thus a large number of derivatives can be synthesized similarly for bioassay.This provides a new approach for the research and development of Panax notoginseng.

关 键 词：人参二醇 人参二醇衍生物 酰化反应 合成 

分 类 号：Q946[生物学—植物学]