2型糖尿病合并非酒精性脂肪肝病患者Chemerin与氧化应激变化及临床意义  

Oxidative Stress and Chemerin Changes and Clinical Significance in Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease

作　　者：张媛[1] 赵国成 

机构地区：[1]西安市第四医院检验科,陕西西安710004 [2]勉县医院检验科,陕西勉县724200

出　　处：《昆明医科大学学报》2014年第6期90-93,共4页Journal of Kunming Medical University

基　　金：陕西省科技攻关基金资助项目(06K11-G4)

摘　　要：目的探讨2型糖尿病合并非酒精性脂肪肝病患者Chemerin与氧化应激状态变化及临床意义.方法选择2型糖尿病患者148例,分为并合非酒精性脂肪肝病组(A组)65例,未合并非酒精性脂肪肝病组(B组)83例,同时选择健康人50例作为对照组(C组).分别检测肝功能及Chemerin及氧化应激状态.结果 A组ALT、AST及Chemerin较C组均存在显著性升高(P<0.05),Chemerin较B组显著升高(P<0.05).B组Chemerin较C组有显著升高(P<0.05).A组MDA、SOD、GSH较B、C组有显著统计学差异(P<0.05).B组MDA、SOD较C组存在显著性差异(P<0.05).ALT、AST与MDA、SOD、GSH未见显著相关性(P>0.05).Chemerin与MDA显著正相关(P<0.05),与SOD、GSH均显著负相关(P<0.05).结论氧化应激状态及Chemerin评估在反映2型糖尿病合并非酒精性脂肪肝病脂代谢等方面具有较好的相关性,有助于监测肝脏病变进展.Objective To study oxidative stress and chemerin changes and clinical significance in Type 2 diabetes with nonalcoholic fatty liver disease patients.Methods 148 patients with type 2 diabetes were divided into non-alcoholic fatty liver disease group （group A）,unconsolidated non-alcoholic fatty liver disease group （B group）,while 50 cases healthy people were chosen as a control group （group C）.Liver function and Chemerin and oxidative stress were detected.Results ALT,AST and Chemerin of A group were significantly higher than group C （P＜0.05）,Chemerin was significantly higher than group B （P＜0.05） Chemerin of group B was significantly higher than in group C （P＜0.05）.A group of MDA,SOD,GSH showed significant difference with B,C group （P＜0.05）.MDA,SOD of Group B had a significant difference with C group （P＜O.05）.ALT,AST and MDA,SOD,GSH showed no significant correlation （P＞0.05）.Chemerin was significantly correlated with MDA （P＜0.05）,and SOD,GSH was significantly negatively correlated （P＜0.05）.Conclusion The assessment of oxidative stress status and chemerin can reflect type 2 diabetes mellitus in nonalcoholic fatty liver lipid metabolism and have a good correlation,which would help monitor the progress of liver disease.

关 键 词：2型糖尿病 非酒精性脂肪肝病 CHEMERIN 氧化应激变 

分 类 号：R587.1[医药卫生—内分泌]