新型委陵菜黄酮衍生物对四氧嘧啶诱导糖尿病小鼠血糖血脂的影响  

Antihyperglycemic and antihyperlipidemic effects of the novel flavonoid derivatives of potentilla chinensis on alloxan diabetic mice

作　　者：梁艳[1] 段宏泉[1] 秦楠[2] 周雯[1] 靳美娜[1] 乔卫[1] 

机构地区：[1]天津医科大学药学院,天津市临床药物关键技术重点实验室,天津300070 [2]天津医科大学基础医学研究中心,天津300070

出　　处：《天津医科大学学报》2014年第3期169-171,共3页Journal of Tianjin Medical University

基　　金：国家自然科学基金面上项目(81373297);天津市自然科学基金重点项目(12JCZDJC25900)

摘　　要：目的:研究4个新型委陵菜黄酮衍生物对四氧嘧啶诱导的糖尿病小鼠血糖血脂水平的影响。方法:用四氧嘧啶制备糖尿病小鼠模型,研究不同结构的新型委陵菜黄酮衍生物A^D分别给予不同剂量灌胃给药(10、30 mg·kg-1)对糖尿病小鼠血糖、血脂的影响。结果:4个新型委陵菜黄酮衍生物均可显著降低糖尿病小鼠的血糖和血清甘油三酯水平。除衍生物B外,其它各给药组均能明显降低糖尿病小鼠的血清总胆固醇水平。结论:新型委陵菜黄酮衍生物对四氧嘧啶诱导的糖尿病小鼠均具有较好的降血糖和降血脂作用,衍生物D是更具有进一步研究价值的抗糖尿病候选化合物。Objective： To study the antihyperglycemic and antihyperlipidemic effects of novel flavonoid derivatives of potentilla chinensis on alloxan diabetic mice. Methods： The diabetic mice were induced by ALX in KM mice. The effects of blood glucose and blood lipid were investigated after administration of the different dosages （10,30 mg＇kg-I） of the derivatives（A-D）. Results： Derivatives （A, C, D） could not only decrease the blood glucose levels but also decrease the levels of cholesterol and triglyceride in serum of diabetic mice. Derivative B, however, could only decrease the blood glucose and the levels of CHO in serum. Conclusion： The new type potentilla chinensis＇ flavonoid derivatives have significant effects on diabetic mice with derivative D having more potential.

关 键 词：新型委陵菜黄酮衍生物 四氧嘧啶 血糖 血脂 小鼠 

分 类 号：R587.1[医药卫生—内分泌]