瑞舒伐他汀强化治疗对心肌梗死患者PCI术后APN、BNP的影响  

Effect of rosuvastatin intensive treatment on APN, BNP of myocardial infarction after PCI

作　　者：刘振吉[1] 赵树芬[1] 张玉榕[1] 

机构地区：[1]滨州市人民医院,256610

出　　处：《国际医药卫生导报》2014年第9期1229-1232,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨瑞舒伐他汀强化治疗对心肌梗死患者冠状动脉介入术（PCI）术后脂联素（APN）、脑钠肽（BNP）的影响及机制.方法 选择96例急性心肌梗死早期行PCI术后合并心力衰竭的患者,随机分为对照组32例（一般治疗）、治疗组32例（瑞舒伐他汀,10 mg/d）和强化组32例（瑞舒伐他汀,20 mg/d）,记录住院期间及院外不良事件的发生.治疗组和强化组患者术前1周在一般治疗的基础上开始服用上述药物,术后第1天、第4周及第8周空腹,取血清分别用EL]SA法和酶谱法检测APN、BNP浓度.结果 PCI术后第1天、第4周及第8周血浆中APN水平较术前明显升高（P＜ 0.05）术后第4周、第8周强化组较治疗组和对照组相比,血浆中APN水平明显升高（P＜0.05）.PCI术后第1天、第4周及第8周血浆中BNP水平较术前明显降低（P＜0.05）;术后第4周、第8周强化组较治疗组和对照组相比,血浆中BNP水平明显降低（P＜0.05）.结论 本研究显示瑞舒伐他汀强化治疗可显著升高血浆中APN水平,降低血浆中BNP水平,从而保护冠脉血管内皮细胞,降低支架内再狭窄的发生,效果优于瑞舒伐他汀普通剂量治疗.Objective To explore the effect of rosuvastatin intensive treatment on APN,BNP of myocardial infarction patients after PCI.Methods Ninety-six patients with acute myocardial infarction undergoing PCI with heart failure,were randomly divided into the control group of 32 cases （general treatment）,and the treatment group of 32 patients （rosuvastatin,10 mg/d） and intensive group of 32 examples （rosuvastatin,20 mg/d）,then we recorded the occurrence of adverse events during hospitalization and outside the hospital.On the basis of the general treatment one week prior to the treatment group and the intensive group patients taking these drugs,the first day after surgery,four weeks and eight weeks of fasting,take APN,BNP concentrations in serum were detected by ELISA and zymography.Results ① The plasma APN levels of PCI postoperative day 1,four weeks and eight weeks were significantly higher than those before surgery （P ＜ 0.05）.After four weeks and eight weeks,the plasma APN levels of intensive group were significantly increased compared to the treatment and control groups （P ＜ 0.05）; ② One day after PCI,4 weeks and 8 weeks,the plasma BNP levels were significantly lower than preoperative （P ＜ 0.05）.After four weeks and eight weeks,compared to the treatment and control groups,the plasma BNP levels of rosuvastatin intensive group were significantly lower （P ＜ 0.05）.Conclusion Rosuvastatin intensive treatment can significantly increase the plasma APN level and reduce BNP level,thereby protecting the coronary vascular endothelial cells and reducing the occurrence of in-stent restenosis,better than the dose rosuvastatin therapy through.

关 键 词：瑞舒伐他汀 强化治疗 PCI APN BNP 

分 类 号：R542.22[医药卫生—心血管疾病]