川芎嗪注射液对鼠脑损伤后神经细胞的保护及功能恢复作用  

Protective effect and recovery function of ligustrazine on rats brain injury

作　　者：黄剑 陈喜德[2] 李少鹏[3] 魏长新 蔡学坚 陈苑新 何贵文 

机构地区：[1]东莞市大岭山医院神经外科,523820 [2]广东医学院东莞校区外科教研室,523820 [3]东莞市人民医院神经外科,523800

出　　处：《国际医药卫生导报》2014年第9期1232-1234,共3页International Medicine and Health Guidance News

摘　　要：目的 研究川芎嗪注射液（GBE）对大鼠脑损伤后神经细胞的保护及功能恢复作用.方法 50只Wistar雄性大鼠随机分为对照组和治疗组,每组25只,对照组：液压损伤法损伤脑后腹腔注射等渗盐水;治疗组：脑损伤后1h腹腔注川芎嗪注射液10 mg/kg,此后2次/d,持续治疗5d.末次治疗后每组处死5只动物,检测脑组织超氧化物歧化酶（SOD）活性、丙二醛（MDA）和一氧化氮（NO）含量,脑损伤后第1h和末次治疗后第1、5、10d评定四肢运动功能（Salzman评分）和检测诱发电位（MEP）.结果 SOD活性治疗组高于对照组（P＜0.05）,MDA和NO含量治疗组低于对照组（P＜ 0.05）.脑损伤后,四肢运动障碍,MEP波幅（P1-N1峰峰值）降低,潜伏期延长,末次治疗后各时间,治疗组MEP波幅、潜伏期,神经功能恢复均优于对照组（P＜0.05）.结论 川芎嗪注射液能减少脑损伤后氧自由基所致继发损伤,并促进神经功能恢复.Objective To study the protective effects and recovery function of ligustrazine on rats brain injury.Methods 50 wistar male rats were randomly divided into 2 groups：A （control group）; B （ligustrazine group）.group B treated with ligustrazine 10 mg/kg was respectively intraperitoneally injected into the rats 1 hour after SCI,then given ligustrazine at a day interal for 5 days.After the last treatment the each group 5 rats were killed and the levels of SOD,MBA and NO were measured and after last treatment 1,5,10 days motor function of 4 limbs was evaluated and MEP was recorded.Result The levels of SOD in group B was significantly higher than that in group A （P ＜ 0.05） and the level of MDA,NO in group B was significantly lower than that in group A （P ＜ 0.05）.Distinct handicap of motor function in 4 limbs presented and amplitudes （Peak-Peak between P1 and N1） of MEP reduced,amplitudes in group B recovered better than that in group A at each measured time （P ＜ 0.05）.Conclusion Ligustrazine can decrease the production of free radicals after brain injury and accelerate undee reversion of MEP and promote motor function recovery of braine injury undee restoration of MEP began earlier than that of motor function of 4 limbs.

关 键 词：川芎嗪注射液 脑损伤 超氧化物歧化酶 功能恢复 

分 类 号：R285.5[医药卫生—中药学]