聚(L-乳酸)体内外降解相关性研究  

Poly( L-lactic acid) degradation correlation study in vivo and in vitro

作　　者：鲍时根[1,2] 张云[1,2] 朱玉俊[1,2] 杨怀志 杜军 马建华[1,2] 

机构地区：[1]合肥工业大学控释药物研究所,安徽合肥230009 [2]安徽中人科技有限责任公司,安徽合肥230088

出　　处：《安徽医药》2014年第5期808-810,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金(No C03031702);科技型中小企业技术创新基金(No 12C26213403306)

摘　　要：目的考察聚(L-乳酸)(PLLA)植入剂体内外降解特性黏数和失重变化的相关性。方法以辛酸亚锡为催化剂,通过直接缩聚法制备聚(L-乳酸)(PLLA)树脂,经精制得药用辅料;将药用辅料通过特定设备压制成空白植入剂,考察其在大白兔体内的降解情况,并与其在pH7.4的磷酸盐缓冲液的体外降解相比较。结果聚(L-乳酸)植入剂样品降解后的特性黏数与降解时间(wk)呈指数关系,失重百分率与降解时间(wk)呈线性关系。结论体内的特性黏数与体外的特性黏数数值相近,体外失重比体内快。Objective To investigate the correlation of intrinsic viscosity and weightlessness in vivo and in vitro degradation of poly（Llactic acid）（ PLLA） implants. Methods Stannous octoate as a cataly,through polycondensation preparation of poly（ L-lactic acid）（PLLA） resin,was refined to obtain a pharmaceutic excipient,which was pressed into the blank implants by a particular device. We studied its characteristics of degradation in rabbits in vivo,and compared with its degradation in phosphate buffer in vitro. Results Intrinsic viscosity of poly（ L-lactic acid） was exponentially related to the degradation time（ wk）,while that weightlessness showed a linear correlation of the degradation time（ wk）. Conclusions The intrinsic viscosity numbers of poly（ L-lactic acid） in vivo are similar to that in vitro. The weight of poly（ L-lactic acid） reduces faster in vitro than that in vivo.

关 键 词：聚(L-乳酸) 直接缩聚 体内外降解 特性黏数 失重 

分 类 号：R318.08[医药卫生—生物医学工程]