唾液皮质醇与血浆皮质醇、尿游离皮质醇测定的相关性分析及其临床价值  

Correlation analysis of salivary cortisol,plasma cortisol and urinary free cortisol and its clinical value

作　　者：赵广碧[1] 贾丽[1] 储小宏[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌实验室,安徽合肥230022

出　　处：《安徽医药》2014年第5期868-870,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨正常人唾液皮质醇、血浆皮质醇和24 h尿游离皮质醇三者之间的相关性。方法选择30例健康受试者同时检测唾液皮质醇、血浆皮质醇和24 h尿游离皮质醇。男子组和女子组各15例。采用化学发光技术测定,唾液标本采用唾液收集器收集,血标本为血浆,24 h尿液标本用硼酸防腐。结果唾液皮质醇和血浆、24 h尿液皮质醇在正常男女组之间均无显著性差异(P>0.05),唾液皮质醇与血浆皮质醇(r=0.91)、唾液皮质醇与24 h尿游离皮质醇(r=0.95),均存在显著的相关性。结论唾液皮质醇可作为库欣氏综合征的筛查指标。Objective To investigate the correlation among normal salivary cortisol,plasma cortisol and 24-hour urine free cortisol of healthy human beings. Methods A total of 30 healthy subjects were selected and equally divided into male group and female group. The levels of salivary cortisol,plasma cortisol and 24-hour urine free cortisol were detected by chemiluminescence technique. Salivary specimens were collected using salivary collector. Blood specimens were blood plasma. 24-hour urine specimens were antisepticized by using boric acid. Results The levels of salivary cortisol,plasma cortisol and 24-hour urine free cortisol showed no significant difference between male group and female group（ P 〉 0. 05）. The correlation analysis results showed that the levels of three kinds of cortisol were highly related（ P 〈 0. 001）. Conclusions Salivary cortisol testing can be used as screening indicator of Cushing＇s syndrome.

关 键 词：唾液皮质醇 血浆皮质醇 尿游离皮质醇 相关性 

分 类 号：R586.2[医药卫生—内分泌] R587.1[医药卫生—内科学]