5-乙酰基-6-甲基-4-苯基-3,4-二氢嘧啶-2-酮的合成  

Synthesis of 5-acetyl-6-methyl-4-phenyl-3,4-dihydrogenpyrimidine-2-one

作　　者：吴泽波[1] 孙婷[1] 

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《广州化工》2014年第9期58-59,62,共3页GuangZhou Chemical Industry

基　　金：河南省教育厅自然科学研究项目(2011A150025)

摘　　要：采用固体超强酸SO42-/ZrO2-SiO2为催化剂,以乙酰丙酮、苯甲醛、尿素为原料,以无水乙醇为溶剂,在加热回流条件下合成5-乙酰基-6-甲基-4-苯基-3,4-二氢嘧啶-2-酮,产率为73.9%。该反应条件温和,反应时间短(3 h),后处理简便,产率高(73.9%),并且固体超强酸SO42-/ZrO2-SiO2具有容易制备,易与产物分离,价廉等优点,是一种合成3,4-二氢嘧啶-2-酮类化合物高效的方法。5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2-one was synthesized with catalyst of solid super acid（ SO4^2-/ ZrO2-SiO2）,solvent of ethanol,and aromatic aldehydes,acetylacetone and urea by refluxing under the conditions of stirring,and the yield can reach 73. 9%. The characteristics of reaction were mild reaction conditions,short reaction time（ 3 h）,simple post-processing,and high yield（ 73. 9%）. The better method of synthesis of 5-acetyl-6-methyl-4-phenyl-3,4-dihydrogenpyrimidine-2-one by solid superacid SO42-/ ZrO2-SiO2had the characteristics of easy preparation,easy to separate,and low price.

关 键 词：BIGINELLI反应 固体超强酸SO42-/ZrO2-SiO2 3 4-二氢嘧啶-2-酮 

分 类 号：O626.3[理学—有机化学]