调节性B细胞在感染免疫中的作用研究进展  

Regulatory B cells in immunity from infection

作　　者：刘学磊[1,2] 刘玉梅[1] 丁剑冰[2] 马秀敏[1,2] 

机构地区：[1]新疆医科大学第一附属医院、新疆重大疾病医学重点实验室一省部共建国家重点实验室培育基地,新疆乌鲁木齐830011 [2]新疆医科大学基础医学院

出　　处：《中国病原生物学杂志》2014年第4期381-383,共3页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81260253,31160194,30960358,81160200,81060135);新疆维吾尔自治区自然科学基金项目(No.2012211A034)

摘　　要：B细胞主要通过呈递抗原和产生抗体发挥免疫调节作用。近年来研究发现部分B细胞具有调节功能,这部分B细胞被命名为调节性B细胞(regulatory B cells,Bregs)。Bregs可通过产生白细胞介素10(IL-10)和(或)转化生长因子β1(TGF-β1)等抑制性细胞因子介导免疫耐受,抑制过度炎症反应,加快炎症的恢复。相关研究表明Bregs在寄生虫、细菌、病毒感染中发挥重要作用。本文综述了Bregs的生物学特征、功能、微信号调节及其在感染性疾病中所发挥的作用机制及相关研究进展。B cells display their ability to regulate the immune response by presenting antigens and producing antibodies.Recent studies indicate that some B cells,known as regulatory B cells or Bregs,have a regulatory function.By producing immunosuppressive cytokines such as interleukin-10（IL-10）and transforming growth factorβ1（TGF-β1）,Bregs are involved in immune tolerance,inhibition of excessive inflammation,and acceleration of recovery from inflammation.Research indicates that Bregs play an important role in parasite,bacterial,and viral infections.This review summarizes recent insights into the biological characteristics,function,and the micro-environmental signaling of Bregs and the role they play in infectious diseases.This review also describes advances in research related to Bregs.

关 键 词：调节性B细胞 感染免疫 IL-10 TGF-Β 综述 

分 类 号：R37[医药卫生—病原生物学]