急性冠脉综合征患者血浆IL-37水平变化及意义  

Plasma IL-37 levels in patients with acute coronary syndrome

作　　者：黄瑛[1] 林英忠[2] 施莹[2] 陆政德[2] 刘伶[2] 王小燕[1] 吉庆伟[2] 

机构地区：[1]广西壮族自治区人民医院超声科,南宁市530021 [2]广西壮族自治区人民医院心内科,南宁市530021

出　　处：《实用医学杂志》2014年第10期1559-1561,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81160045)

摘　　要：目的:探讨急性冠脉综合征患者血浆IL-37水平的变化。方法:连续入选稳定型心绞痛(SA)组(40例),不稳定型心绞痛(UA)组(65例)和急性心肌梗死(AMI)组(47例)。同期冠脉造影正常的60例胸痛综合征患者为对照组。采用夹心酶联免疫法(ELISA)测定血浆IL-37水平,采用免疫发光夹心法检测CRP水平,电化学发光法检测NT-proBNP水平。结果:UAP组和AMI组血浆IL-37、CRP和NT-proBNP水平显著高于对照组和SAP组。冠心病患者IL-37水平与CRP、NT-proBNP水平正相关,与LVEF显著负相关。结论:血浆IL-37水平变化可能与急性冠脉综合征的出现密切相关。Objective To evaluate the role of plasma IL-37 levels in patients with acute coronary syndrome（ACS）. Methods Plasma biomarkers IL-37, CRP and NT-proBNP levels were measured in 40 patients with stable angina pectoris（SA group）, 65 patients with unstable angina pectoris（UA group）, 47 patients with acute myocardial infarction（AMI group） and 60 control patients. Results The plasma IL-37, CRP and NT-proBNP levels were significantly increased in patients with ACS patients. A correlation analysis showed that the plasma IL-37 levels were positively correlated with the levels of CRP and NT-proBNP, and negatively correlated with LVEF. Conclusions The results indicated that the plasma IL-37 levels are associated with the onset of ACS symptoms.

关 键 词：急性冠脉综合征 IL-37 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]