干扰素α-2b对早孕合并细菌性阴道病绒毛超微结构及Caspase-3表达的影响  

The effect of interferon alfα-2b on the ultrastructure and Caspase-3 levels in villus in early pregnancy with bacterial vaginal disease

作　　者：袁媛[1] 张宇骄[1] 傅晓冬[1] 

机构地区：[1]泸州医学院附属医院妇产科,646000

出　　处：《实用医学杂志》2014年第10期1632-1634,共3页The Journal of Practical Medicine

基　　金：四川省卫生厅科研项目基金资助(编号:070268)

摘　　要：目的:探讨IFNα-2b对早孕合并细菌性阴道病绒毛滋养细胞超微结构及滋养细胞Caspase-3表达的影响。方法:早孕合并细菌性阴道病要求终止妊娠妇女25例为治疗组,予以重组人IFNα-2b栓治疗;同期正常早孕妇女30例为对照组。透射电镜观察绒毛滋养细胞超微结构及免疫组化SP法检测绒毛滋养细胞Caspase-3的表达水平。结果:两组滋养细胞凋亡现象无明显差别;两组滋养细胞Caspase-3的表达水平差异无统计学意义(P>0.05)。结论:IFNα-2b治疗早孕合并细菌性阴道病未发生绒毛滋养细胞的过度凋亡。Objective To investigate the effect of interferon alfα-2b on the ultrastructure and Caspase-3 levels in villus in early pregnancy with bacterial vaginal disease（BV）. Method Early pregnant women were divided into two groups. The treated group included 25 early pregnant women with BV who chose to have an early termination and were treated with rhINFα-2b. The controling group included 30 early pregnant women without any genital tract infectious diseases. The caspase-3 levels in trophocytes were detected by immunochemistry and the ultrastructural changes were observed in villus by transmission electron microscopy. Result（1）There was no apparent difference of ultrastructural changes between the two groups.（2）There was no statistical significance of the levels of caspase-3 between the two groups（P〉0.05）. Conclusion The excessive apoptosis do not occur in the trophocytes when treated with INFα-2b.

关 键 词：干扰素Α-2B CASPASE-3 绒毛 超微结构 

分 类 号：R714.258[医药卫生—妇产科学]