雌激素对神经保护的作用机制  

Mechanisms of estrogen's neuroprotective effects

作　　者：李婷[1] 张渺[1] 

机构地区：[1]北京大学第一医院妇产科,北京100034

出　　处：《中国性科学》2014年第4期33-35,共3页Chinese Journal of Human Sexuality

摘　　要：雌激素作为一种类固醇激素,除具有生长、发育、生殖功能方面的作用外,还具有保护神经细胞的作用,但该神经保护作用机制尚未明确。目前的机制研究主要集中于三大途径,即经典的雌激素核受体介导的基因组作用机制、非基因组MAPK-ERK或PI3K-Akt作用机制以及不依赖于受体的抗氧化作用机制。每个机制之间相互联系,共同作用产生神经保护效应。每一个通路所发挥的作用可能随组织类型、神经类型、受体表达情况和神经细胞外界微环境等因素的不同而发生改变。Estrogen,a gonadal steroid hormone,functions in growth,development and reproduction,estrogen.It also plays a role in neuroprotection but the mechanism remains controversial.So far,three main proposals have been proposed to explain how estrogen protects the nervous system,including the classic genomic estrogen receptor（ER）-mediated mechanism,a nongenomic mechanism involving mitogen- activated protein kinase（MAPK）- extracellular signal- related kinases（ERK） and / or phosphotidylinositol- 3- kinase（PI3K）- Akt signaling,and a receptor- independent antioxidant free- radical scavenging mechanism.Intercommunication has been hypothesized to exist among three mechanisms,creating a function of neuroprotection.The effects of each signaling would be changed by different factors,including tissue or nerve type,expression of receptors and extracellular microenvironment.

关 键 词：雌激素 雌二醇 神经保护作用 雌激素受体 

分 类 号：R167[医药卫生—公共卫生与预防医学]