卵巢黄素化颗粒细胞与胚胎质量和妊娠结局关系的探讨  

Relationship between ovarian luteinization granulosa cell,embryo quality and IVF-ET pregnancy outcome

作　　者：张鑫[1] 邓锴[1] 罗清炳[1] 徐鸿毅[1] 张昌军[1] 

机构地区：[1]湖北医药学院附属人民医院生殖医学中心,湖北十堰420000

出　　处：《中国性科学》2014年第5期82-85,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨在辅助生殖技术中卵巢黄素化颗粒细胞与胚胎质量和妊娠结局的关系。方法:回顾性分析2012年1月至2013年5月因输卵管性因素不育到十堰市人民医院生殖医学中心行IVF-ET的患者,选取全部卵巢黄素化颗粒细胞的110例患者作为黄素化颗粒细胞组,随机选择同期颗粒细胞形态无异常的335例患者作为颗粒细胞形态正常组,比较两组间受精、早期胚胎发育、囊胚形成及妊娠结局的差异。结果:颗粒细胞形态正常组与黄素化颗粒细胞组之间的受精率、优质胚胎率、可利用胚胎率及囊胚形成率差异均有统计学意义(P<0.05),两组间的新鲜周期胚胎着床率、临床妊娠率和流产率差异无统计学意义(P>0.05)。结论:卵巢黄素化颗粒细胞可能影响其受精、胚胎发育及囊胚的形成。Objectives： To investigate the relationship between ovarian luteinization granulosa cells,embryo quality and regnancy outcome in assisted reproductive technology. Method： Research objects were selected through retrospective analysis from the IVF- ET patients visiting Center for Reproductive Medicine of People＇s Hospital Affiliated to Hubei University of Medicine from January 2012 to May 2013 due to oviduct factors. 110 patients with ovarian luteinization granulosa cells were regarded as group of luteinization granulosa cells,while 335 patients with no abnormal particle morphology were randomly selected as the normal group. The fertilization,early embryonic development,blastocyst formation and pregnancy outcome of the groups were compared. Results： The differences of fertilization rate,high quality embryo rate,available embryo rate and blastocyst formation rate between the 2 groups were statistically significant（ P〈0. 05）; the embryo implantation rate,clinical pregnancy rate and abortion rate in freshcycles between the 2 groups was of no significant difference（ P〉0. 05）. Conclusion： Ovarian luteinization granulosa cells may affect the fertilization,embryo development and blastocyst formation.

关 键 词：辅助生殖技术 胚胎 颗粒细胞 

分 类 号：R711.75[医药卫生—妇产科学]