正交试验对3,3-亚戊基丁内酰胺合成工艺优化  

The synthetic optimization of 3,3-pentamethylene-4-butyrolactam with orthogonal experiment

作　　者：郭翠红 董津 陈晓飞 张海燕 杨秋亚 

机构地区：[1]河北诚信有限责任公司,河北石家庄051130

出　　处：《精细与专用化学品》2014年第5期49-51,共3页Fine and Specialty Chemicals

摘　　要：由1,1-环己基二乙酸单酰胺开始,制备3,3-亚戊基丁内酰胺。3,3-亚戊基丁内酰胺是合成抗癫痫药物加巴喷丁的中间体。通过正交实验筛选出影响其产率的主要因素为盐酸的加量,并通过实验确定了最佳n(盐酸)∶n(1,1-环己基二乙酸单酰胺)为2.0∶1,环合时间为180min,在这种条件下达到了最高收率75.21%。3,3-Pentamethylene-4-butyrolactam is the intermediate of Gabapentin which was antiepileptic drugs.3,3-Pentamethylene-4-butyrolactam was synthesized using 1,1-cyclohexyl diacetate monoamide as starting material.Through orthogonal experiment,optimum rection conditions were ascertained as follws∶n（hydrochloric acid）∶n（1,1-cyclohexyl diacetate monoamide）=2.0∶1,the reaction time of 180min,the yield of 3,3-pentamethylene-4-butyrolactam reach 75.21%.

关 键 词：3 3-亚戊基丁内酰胺 反应时间 1 1-环己基二乙酸单酰胺 

分 类 号：TQ225.261[化学工程—有机化工]