金水宝胶囊对桥本氏甲状腺炎自身抗体的影响及量效关系  

Effect of Jinshuibao Capsules on Thyroid Autoantibodies in Patients with Hashimoto Thyroiditis and Their Dose-effect Relationship

作　　者：曾慧妍[1] 赵玲[1] 王璟霖 宋薇[1] 张锦明[1] 吴露露[1] 

机构地区：[1]广东省中医院内分泌科,广东广州510120 [2]广州中医药大学

出　　处：《广州中医药大学学报》2014年第3期357-360,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】探讨不同剂量的金水宝胶囊对桥本氏甲状腺炎患者自身抗体的影响及其量效关系。【方法】将127例桥本氏甲状腺炎患者随机分为4组:对照组、西维尔组、低剂量金水宝+西维尔组(中药低剂量组)、高剂量金水宝+西维尔组(中药高剂量组),治疗24周。观察各组甲状腺功能[血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)]及血清抗甲状腺过氧化物酶抗体(anti-TPOAb)、抗甲状腺球蛋白抗体(anti-TGAb)水平的变化。【结果】治疗24周后,各治疗组的anti-TPOAb及anti-TGAb滴度均显著下降(P<0.05),其中与西维尔组比较,2个联合治疗组的antiTPOAb及anti-TGAb滴度下降幅度更为显著(P<0.05)。在联合治疗中,金水宝胶囊呈剂量依赖性显著降低血中anti-TPOAb滴度(分别降低65.5%、86.2%),不同剂量组间比较差异有统计学意义(P<0.05);不同剂量金水宝胶囊对血中anti-TGAb滴度的降低程度则无明显差异(分别降低57.7%、58.2%),不同剂量组间比较差异无统计学意义(P>0.05)。对照组治疗24周后血中anti-TPOAb及anti-TGAb水平均无明显变化(P>0.05)。【结论】西维尔及金水宝均有一定程度降低甲状腺自身抗体的作用,金水宝联合西维尔的疗效优于单用西维尔;金水宝对甲状腺自身抗体的影响存在明显的量效关系。Objective To explore the effects of various doses of Jinshuibao Capsules （JC） on thyroid autoantibodies in patients with Hashimoto thyroiditis and to explore their dose-effect relationship. Methods A total of 127 patients with Hashimoto thyroiditis were enrolled into the study, and then were randomly divided into four groups, namely control group, Selenious Yeast Tablets group, low-dose JC combination group, and high-dose JC combination group. The treatment lasted for 4 weeks. Thyroid function indexes including serum free triiodothyronine （FT3）, free thyroxine （FT4） and thyroid-stimulating hormone （TSH） were examined, and the serum levels of anti-thyroid peroxidase antibody （anti-TPOAb） and anti-thyroglobulin antibody （anti-TGAb） were also detected in various groups. Results After treatment for 24 weeks, anti-TPOAb titer and anti-TGAb titer were decreased in all medication groups to various degrees （P〈0.05 compared with those before treatment）, and the decrease was obvious in the two combination groups compared with Selenious Yeast Tablets group （P〈0.05）. In the combination groups, the decrease of anti-TPOAb titer was in dose-dependent manner, and the decrease rate was 65.5% in low-dose JC combination group and was 86.2% in high-dose JC combination group, the difference being significant （P〈0.05）. The decrease rate of anti-TGAb titer was 57.7% in low-dose JC combination group and was 58.2% in high-dose JC combination group, the difference being insignificant （P〉 0.05） . In the control group, the serum anti-TPOAb and anti-TGAb levels stayed steady before and after treatment （P〉0.05）. Conclusion Both JC and Selenious Yeast Tablets show certain effect on decreasing the serum thyroid autoantibodies in patients with Hashimoto thyroiditis, and the combined use has better effect than Selenious Yeast Tablets alone. The effect of JC on thyroid autoantibodies is dose-dependent.

关 键 词：金水宝胶囊 桥本氏甲状腺炎 抗甲状腺过氧化物酶抗体 抗甲状腺球蛋白抗体 

分 类 号：R581.4[医药卫生—内分泌]