子宫内膜异位症患者血清中SDC-1、sHLA-G及MMP-9表达水平变化及意义  

Changes of expression levels and significances of serum SDC-1,sHLA-G and MMP-9 in patients with endometriosis

作　　者：王平[1] 朱新群[1] 张朋丽[1] 

机构地区：[1]郑州大学第二附属医院妇产科,河南郑州450014

出　　处：《中国妇幼保健》2014年第15期2327-2329,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨子宫内膜异位症（EMS）患者血清中多配体蛋白聚糖-1（SDC-1）、可溶性人类白细胞抗原-G（sHLA-G）、金属基质酶-9（MMP-9）的表达水平变化及意义。方法：随机选取88例EMS患者（Ⅰ～Ⅱ期及Ⅲ～Ⅳ期各44例）,采用ELISA法检测血清中SDC-1、sHLA-G、MMP-9的表达水平,同时与35例同期健康体检的妇女对比。结果：SDC-1、sHLA-G、MMP-9在EMS患者血清中的表达水平明显高于对照组,差异有统计学意义（P〈0.01）;Ⅲ～Ⅳ期EMS患者血清中SDC-1、sHLA-G、MMP-9的表达水平均高于Ⅰ～Ⅱ期,差异有统计学意义（P〈0.01）;EMS组SDC-1和MMP-9之间呈正相关（r=0.683,P〈0.05）;sHLA-G与MMP-9之间呈正相关（r=0.456,P〈0.05）;三者联合检测诊断EMS的敏感度、特异性分别为93.18%、94.28%。结论：SDC-1、sHLA-G、MMP-9可能在EMS的发生、发展过程发挥重要作用;联合检测SDC-1、sHLA-G、MMP-9有望成为EMS的无创诊断的新指标。Objective： To explore the changes of expression levels and significances of serum SDC - 1, sHLA - G and MMP - 9 in patients with endometriosis. Methods： A total of 88 patients with endometriosis were randomly selected as endometriosis group, including 44 patients of stage Ⅰ- Ⅱ and 44 patients of stage Ⅲ -Ⅳ, 35 women receiving healthy physical examination during the same period were se- lected as control group; ELISA was used to detect the expression levels of SDC - 1, sHLA - G and MMP - 9. Results： The expression lev- els of serum SDC - 1, sHLA - G and MMP -9 in endometriosis group were statistically significantly higher than those in control group （P 〈 0.05 ） ; the expression levels of serum SDC - 1, sHLA - G and MMP - 9 in endometriosis group of stage ]II- IV were statistically significantly higher than those in endometriosis group of stage Ⅰ- Ⅱ（P 〈 0.01 ） ; in endometriosis group, there was a positive correlation between se- rum SDC - 1 and MMP - 9 （ r = 0. 683, P 〈 0. 05 ）, there was a positive correlation between serum sHLA - G and MMP - 9 （ r = 0. 456, P 〈0. 05） ; the sensitivity and specificity of joint detection of SDC - 1, sHLA - G and MMP -9 were 93.18% and 94. 28%, respectively. Conclusion ： SDC - 1, sHLA - G and MMP - 9 may play important roles in occurrence and development of endometriosis ; joint detection of SDC - 1, sHLA - G and MMP - 9 is expected to be a new serological marker for diagnosing endometriosis noninvasively.

关 键 词：子宫内膜异位症 多配体蛋白聚糖-1 可溶性人类白细胞抗原-G 金属基质酶-9 血清 

分 类 号：R711.71[医药卫生—妇产科学]