基于夹心结构的keggin型铜锑钨酸盐与钆-诺氟沙星的复合膜制备与性质研究  

Study on fabrication and property of mutilayer films based on Keggin-type copper antimony tungstate and Gd-Norfloxacin

作　　者：刘红[1] 李泽[1] 刘建勋[1] 邹玉龙[1] 

机构地区：[1]佳木斯大学药学院,佳木斯154007

出　　处：《化工新型材料》2014年第5期180-182,共3页New Chemical Materials

基　　金：黑龙江省青年科学基金(QC2011C038);黑龙江省杰出青年科学基金(JC201220)

摘　　要：利用层接层自组装技术,以具有抗菌性质的钆-诺氟沙星与夹心结构Keggin型铜锑钨酸阴离子为构筑单元制备了一种新型抗菌纳米复合膜。研究了薄膜的热稳定性及抗菌性能,并通过扫描电镜对其表面形貌进行了研究。研究结果表明：薄膜在0~100℃范围内具有很好的热稳定性,同时也具有很好的杀菌性,对大肠杆菌杀菌12h,杀菌率高达91%±1%;薄膜表面由于多酸或钆-诺氟沙星的聚集形成少量纳米级球形颗粒,但仍具有很好的透明度和光滑度。A new type of multilayer film based on Gd-Norfloxacin and keggin-type polyoxometalate[{Na（H2O）2}3 {Cu（H2O）}3（SbW9O33）2]9-was prepared by using layer-by-layer assembly（LBL）.Thermal stability and antibacterial properties,and its surface morphology were studied by scanning eletron microscopy.Research results showed that：the film had good thermal stability in the range of 0℃to 100℃,but also E.coli starilization 12hours,the starilization rate was up to 91%±1%.The film surface had small amount of nano-sized spherical particles,due to the aggregation of Gd-Norfloxacin or polyoxometalate,but sill had good transparency and smoothness.

关 键 词：层与层自组装 喹诺酮金属配合物 Keggin结构多金属氧酸盐 抗菌 

分 类 号：TQ460.1[化学工程—制药化工]