溃结复发方加减对慢性溃疡性结肠炎患者抗中性粒细胞胞浆抗体的影响  

Effect of Modified Kuijie Fufa Formula on Anti-Neutrophil Cytoplasmic Antibody in Patients With Chronic Ulcerative Colitis

作　　者：刘果[1] 刘大铭[2] 孙慧怡[2] 朱立[2] 周波[2] 王新月[2] 

机构地区：[1]北京中医药大学基础医学院 [2]北京中医药大学东直门医院

出　　处：《中医杂志》2014年第11期927-930,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30572390);国家重点基础研究发展计划("973"计划)资助项目(2009CB522705)

摘　　要：目的观察溃结复发方加减治疗慢性溃疡性结肠炎（UC）的临床疗效及可能作用机制。方法 60例慢性UC患者随机分为治疗组和对照组各30例,治疗组给予溃结复发方加减中药汤药口服,每日1剂;对照组给予柳氮磺胺吡啶肠溶片每日4~6g口服,两组疗程均为3个月,并在治疗后6个月随访。比较两组治疗前后内镜指数评分、组织学炎症分级情况和血清抗中性粒细胞胞浆抗体（ANCA）水平,并判定临床综合疗效及复发情况。结果治疗组综合疗效总有效率为100%、ANCA阴转率为90.91%,明显高于对照组的74.07%、40.00%（P〈0.05或P〈0.01）。两组患者治疗后及随访时内镜指数评分均较本组治疗前明显降低,并且随访时治疗组评分低于对照组（P〈0.05）。随访时治疗组复发率为17.86%,对照组为70.00%,治疗组复发率明显低于对照组（P〈0.01）。结论溃结复发方加减治疗UC疗效优于西药柳氮磺胺吡啶肠溶片,且能降低患者复发率,其作用机制可能和提高患者血清ANCA阴转有关。Objective To observe the therapeutic effect and possible mechanism of modified Kuifie Fufa Formula （ Formula for ulcerative colitis relaps） for chronce ulcerative colitis （ UC ）. Methods Sixty cases of chronic UC were randomized into treatment group and control group, with 30 in each. The patients in the treatment group were orally taken modified Kuijie Fufa Formula one dose daily. The patients in the control group were orally taken 4 g to 6 g sulfasalazine enteric-coated tablets. The treatment lasted for 3 months in both groups. The patients were followed up 6 months after treatment. The endoscopic index score, histological inflammation grade and serum levels of anti- neutrophil cytoplasmic antibody （ANCA） were compared before and after treatment in both groups. The comprehen- sive efficacy and recurrence was determined. Results The comprehensive efficacy and ANCA negative rate was 100% and 90.91% in the treatment group, which was significantly higher than 74.07% and 40.00% in the control group （P 〈 0. 05 or P 〈 0. 01 ）. The endoscopic index scores were significantly decreased in both groups after treat- ment and during the follow-up, especially in the treatment group during the follow-up （ P 〈 0.05 ）. The recurrence rate in the treatment group and control group was 17. 86% and 70. 00% respectively, with a significant difference between groups （P 〈0.01 ）. Conclusion The efficacy of modified Kuijie Fufa Formula is superior to that of sulfasalazine enteric-coated tablets with a lower relapse, which may be relevant to increasing the negative rate of ANCA.

关 键 词：溃疡性结肠炎 溃结复发方 抗中性粒细胞胞浆抗体 

分 类 号：R259[医药卫生—中西医结合]