超声能源在去肾交感治疗中的应用  

Application of Ultrasound in Renal Sympathetic Denervation

作　　者：黄晶[1] 

机构地区：[1]重庆医科大学附属第二医院,重庆400010

出　　处：《中国医疗设备》2014年第5期8-12,共5页China Medical Devices

摘　　要：以SymplicityTM为代表的利用射频能量行去肾交感神经术开创了经皮血管介入治疗顽固性高血压的全新途径。但射频能量消融尚存在消融效率较低、消融时患者疼痛明显、部分患者对治疗无反应(约20%)及完成治疗过程依耐于标准的患者血管类型等缺点。而超声作为一种频率高于听阈的机械波,在生物组织中以纵波传播时,其携带的机械能可使介质中的分子剧烈震荡产生机械摩擦、空化和热效应等,因此可用于去肾交感神经术。且与射频能量消融相比,超声能量在安全性和有效性方面有诸多优势。本综述即将对经导管超声消融肾交感神经相关研究进展作一系统阐述。Renal sympathetic denervation（RDN） with radiofrequency energy is a novel therapeutic technique for the treatment of patients with resistant hypertension. Nevertheless, radiofrequency ablation of renal sympathetic nerves bears numerous disadvantages, e.g., low effi ciency; patient＇s suffering from pain during ablation and unresponsiveness to the treatment, as well as successful procedural performance depending on the type of target vessels, etc. While ultrasound, when longitudinally propagating through the biological tissue, may cause the medium molecules to vibrate violently, with subsequent generation of mechanical friction, cavitation and thermal effects; thus, can be applied for RDN. Compared with radiofrequency energy, it has many advantages in terms of safety and effi cacy. This review is about thestate-of-art of ultrasound ablation for renal sympathetic nerves.

关 键 词：顽固性高血压 去肾交感神经术 超声消融 射频消融 

分 类 号：R197.39[医药卫生—卫生事业管理] R554.1[医药卫生—公共卫生与预防医学]