73例成年支气管哮喘缓解期患者Th1/Th2失衡与健康管理的相关性研究  

Relevance Between Th1/Th2 Imbalance and Health Management：A Study on 73 Cases of Adult Patients with Asthma During Remission Period

作　　者：陈务华[1] 罗仁瀚[1] 李宝国[1] 潘宗奇[2] 何万春[1] 刘志存[1] 谢雅苑 

机构地区：[1]广东省第二中医院,广东广州510095 [2]广东省中医院,广东广州510120

出　　处：《按摩与康复医学》2014年第5期15-17,共3页Chinese Manipulation and Rehabilitation Medicine

基　　金：广东省中医药局科研课题项目,编号：20120110

摘　　要：目的：观察健康管理对成年支气管哮喘缓解期不同证型患者Th1/Th2变化的影响。方法：73例患者分为肺虚型、脾虚型、肾虚型、兼痰浊型及兼瘀血型，随机单盲对照将每型患者分为治疗组和对照组，对照组口服孟鲁司特钠片，治疗组在对照组基础上予以健康管理，检测各组患者治疗前后IFN-γ、IL-4水平并计算IFN-γ/IL-4比值。结果：各证型治疗组IFN-γ、IL-4和IFN-γ/IL-4差值均显著高于对照组（P〈0.05）。结论：哮喘缓解期患者通过系统的健康管理可以改变Th1/Th2失衡，系统健康管理计划对哮喘缓解期起到积极的防治作用。Objective：To observe the influence of health management on the Th1/Th2 change of adult asthma patients with different pattern of syn-drome during remission period. Methods：There were lung deficiency type, spleen deficiency type, kidney deficiency type, turbid phlegm type and blood stasis type in 73 cases of patients, who were randomly divided into treatment group and control group, the control group treated by orally tak-ing montelukast sodium tablets, while treatment group was given health management on the basis of control group＇s treatment, then tested the level of IFN-γ、IL-4 of two groups before and after the treatment and calculated the ratio of IFN-γ/IL-4. Results：The D-value of IFN-γ、IL-4 and IFN-γ/IL-4 of patients with each pattern of syndrome in treatment group were all significantly higher than those of control group （P〈0.05）. Conclusion：The systematic health management can change the Th1/Th2 imbalance status of catabasis asthma patients, which plays a positive role in the prevention of asthma.

关 键 词：支气管哮喘 缓解期 健康管理 TH1/TH2失衡 

分 类 号：R562.25[医药卫生—呼吸系统]