5-氟尿嘧啶壳聚糖缓释微囊制备工艺研究  

Preparation of 5-Fluorouracil Chitosan Sustained Release Microcapsules

作　　者：王奎旗[1] 管华诗[1] 

机构地区：[1]青岛海洋大学海洋药物与食品研究所,青岛266003

出　　处：《青岛海洋大学学报（自然科学版）》2000年第4期614-618,共5页Journal of Ocean University of Qingdao

基　　金：山东省科技攻关计划!( 981 1 64 80 2 )

摘　　要：5-氟尿嘧啶 (5- Fu)以壳聚糖为载体 ,采用乳化化学交联技术 ,制备了 5- Fu壳聚糖微囊。用正交设计安排试验 ,以微囊载药量、药物包封率、粒子分布百分数为指标优化微囊的制备工艺 ,并以最佳制备工艺条件制得含药微囊 ,方法重现性好 ,制备工艺稳定。体外释放度试验表明 ,该微囊具有较好的缓释作用。Cross linked chitosan microcapsules containing 5 Fluorouracil (5 Fu) were prepared. The variable factors believed to be important for microcapsule properties were examined, these included chitosan concentration, the ratio of drug and chitosan concentrations, cross linking process, the type of oil, stirring rate and additives. Seven factors and 3 levels of each factor were chosen and the orthogonal experimental design was applied to optimize the preparation procedure of the microcapsules. The drug release characteristics of the microcapsules were studied. The results indicate that chitosan may prove useful as a carrier for sustained release of drugs.

关 键 词：5-氟尿嘧啶 壳聚糖 乳化化学交联技术 微囊 缓释 制备工艺 抗癌药物 

分 类 号：R979.1[医药卫生—药品]