交让木的生物碱成分研究  

Alkaloids from the Daphniphyllum macropodum Miq.

作　　者：陆云阳 汤海峰[2] 高凯[1] 王啸洋[1] 张伟[1] 马宁[1] 

机构地区：[1]第四军医大学西京医院药剂科,西安710032 [2]第四军医大学药学院药物研究所,西安710032

出　　处：《中南药学》2014年第4期337-340,共4页Central South Pharmacy

摘　　要：目的研究交让木中的生物碱成分。方法样品用95%的乙醇进行提取,所得浸膏用酸-碱处理方法处理后得到总生物碱,之后经正相硅胶、Sephadex LH-20、反向硅胶(RP-18)、高效制备液相等多种色谱方法分离得到生物碱单体,根据其理化性质及波谱学数据鉴定其化学结构。结果分离得到4个虎皮楠生物碱,经鉴定分别为daphniyunnine B(1)、daphmacrodin A(2)、macropodumine B(3)、daphnicyclidin L(4)。结论化合物daphniyunnine B(1)为首次从该植物中分离得到。Objective To investigate alkaloids from Daphniphyllum macropodum Miq.. Methods The stem bark of D.macropodum Miq. was extracted with 95% EtOH, and then the acid-base was used to obtain total alkaloids. Column chromatographies（including silica gel, Sephadex LH-20 and ODS） and preparative HPLC were used to separate the alkaloids and the structures were elucidated on the basis of spectroscopic data. Results Four alkaloids were isolated and identified as daphniyunnine B（1）, daphmacrodin A（2）, macropodumine B（3）, and daphnicyclidin L（4）, respectively. Conclusion Compound 1 has been obtained from D.macropodum Miq. for the first time.

关 键 词：交让木 生物碱 化学成分 

分 类 号：R284.2[医药卫生—中药学] O657.61[医药卫生—中医学]