肠炎宁浸膏粉对大鼠溃疡性结肠炎模型实验研究  

Changyanning extract on ulcerative colitis in rat model

作　　者：马丽 张妙红 邓青 张丹 彭冬冬 潘善庆 曾贵荣 姜德建 

机构地区：[1]湖南省药物安全评价研究中心,长沙410331

出　　处：《中南药学》2014年第4期343-345,共3页Central South Pharmacy

基　　金：科技部新药创制重大科技专项(No.2011ZX09401-301-1)

摘　　要：目的研究肠炎宁浸膏粉对三硝基苯磺酸致大鼠溃疡性结肠炎模型的治疗作用。方法采用三硝基苯磺酸建立大鼠溃疡性结肠炎模型,各组分别给予肠炎宁浸膏粉低、中、高(相当于2.52、5.05、10.1 g生药·kg-1)剂量,连续给药2周,采血检测血清TNF-α、IL-1、IL-6、IL-8水平及结肠组织病理学检查。结果肠炎宁浸膏粉高剂量能明显降低三硝基苯磺酸致大鼠溃疡性结肠炎模型血清TNF-α、IL-8含量(P<0.05或P<0.01),能明显减少三硝基苯磺酸致大鼠溃疡性结肠模型结肠病理改变。结论肠炎宁浸膏粉对溃疡性结肠炎模型具有明显的治疗作用。Objective To study Changyanning extract on ulcerative colitis induced trinitrobenzene sulfonic acid in rats. Methods TNBS was adopted to establish the rat ulcerative colitis model. Experiment groups were given low, medium and high（2.52, 5.05, 10.1 g crude drug·kg^- 1） dose for 2 weeks consecutively, serum levels of TNF-α, IL-1, IL-6, IL-8 level were tested and colon histopathological was examination. Results Changyanning extract high dose significantly reduced TNBS to ulcerative colitis model rats serum TNF-α and IL-8 levels（P〈0.05 or P〉0.01）, could significantly reduce TNBS to ulcerative colon of rats model of colon pathological changes. Conclusion Changyanning extract for ulcerative colitis model have a significant therapeutic effect.

关 键 词：肠炎宁浸膏粉 三硝基苯磺酸 溃疡性结肠炎 

分 类 号：R965[医药卫生—药理学]