妊娠期高血压疾病患者血清胱抑素C和尿微量白蛋白检测的临床意义  

Clinical significance of detection of serum cystatin C combined with urinary microalbumin for patients with hypertensive disorder complicating pregnancy

作　　者：汤素文 曹顺姣[2] 

机构地区：[1]广州市天河区人民医院妇产科,510660 [2]武警广东总队医院番禺分院妇产科

出　　处：《中国实用医药》2014年第10期4-6,共3页China Practical Medicine

摘　　要：目的探讨妊娠期高血压疾病(HDCP)患者血清胱抑素C(Cys-C)和尿微量白蛋白(UmAlb)联合检测的临床价值。方法选择HDCP患者143例,其中,妊娠期高血压68例,轻度子痫前期43例,重度子痫前期32例。另选择同期在本院产前体检的30例正常孕妇作为对照组。分别采血及尿液检测血Cys-C、尿素氮(BUN)、肌酐(Scr)和UmAlb水平并进行比较分析。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组患者血清Cys-C及UmAlb水平均显著高于对照组(P均<0.01);妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组间Cys-C和UmAlb水平比较,差异均有统计学意义(妊娠期高血压组<轻度子痫前期组<重度子痫前期组,P均<0.01)。重度子痫前期组血BUN和Scr水平均明显高于对照组(P<0.01),而妊娠期高血压组、轻度子痫前期组血BUN、Scr水平与对照组比较,差异均无统计学意义(P均>0.05)。结论血清Cys-C和UmAlb均为反映HDCP患者早期肾功能损害的敏感指标,两者联合检测对HDCP早期肾损害的诊断有重要价值。Objective To explore the clinical value of detecting serum cystatin-C（Cys-C） combined with urine microalbumin（UmAlb） for patients with hypertensive disorder complicating pregnancy（HDCP）. Methods 143 patients with HDCP were selected, including pregnancy-induced hypertension of 68 cases, mild pre-eclampsia of 43 cases and severe-eclampsia of 32 cases. Moreover, 30 normal pregnant women were served as control group. The levels of serum Cys-C, blood urea nitrogen（BUN）, serum creatinine（Scr） and UmAlb were detected and compared. Results The levels of serum Cys-C and UmAlb in pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group were significantly higher than the control（P0.01）. There were significantly differences among pregnancy-induced hypertension group, mild pre-eclampsia group and severe-eclampsia group of levels of Cys-C and UmAlb（pregnancy-induced hypertension groupmild preeclampsia groupsevere-eclampsia group, P0.01）. The levels of BUN and Scr of severe-eclampsia group were significantly higher than the control（P0.01）, but they had no significant difference among pregnancyinduced hypertension group, mild pre-eclampsia group and control group（P0.05）. Conclusion Serum Cys-C and UmAlb are sensitive indicators to reflect early renal damage of HDCP patients. Detection of serum Cys-C combined with UmAlb in HDCP patients is helpful to early diagnosis of renal damage.

关 键 词：妊娠期高血压疾病 胱抑素C 尿微量白蛋白 肾损害 

分 类 号：R714.246[医药卫生—妇产科学]