肝转运体的生理变化对中草药研究的影响  

Physiological variations of hepatic transporters in traditional Chinese medicine research

作　　者：刘杰[1,2] 朱琼妮[2] 侯玮钰 陆远富[2] 

机构地区：[1]University of Kansas Medical Center [2]遵义医学院药理学教研室暨教育部-贵州省共建基础药理重点实验室,贵州遵义563099

出　　处：《遵义医学院学报》2014年第2期138-143,共6页Journal of Zunyi Medical University

基　　金：贵州省科技厅药物代谢平台项目(NO:新药药理与毒理023);国家自然科学基金项目(NO:81160415);贵州省教育厅研究生教育创新基地项目(NO:黔科2008-002);遵义医学院博士启动基金(NO:F-582)

摘　　要：中草药的药物相互作用在传统中药的研究过程中越来越重要。中草药与其它药物的合用可能会影响药物的药物代谢动力学与药物效应学,从而增加/减弱其药效或毒性作用。药动学包括吸收、分布、代谢及排泄,药物代谢的主要器官在肝脏,而肝转运体在药物相互作用中起重要作用。本文探讨了肝转运体在生长发育,衰老过程,时辰,妊娠和哺乳的生理变化及吴茱萸次碱对肝药物转运体的影响。Herb- drug interactions are becoming more and more important in traditional medicine research. Herb - drug interactions affect the prescribed drugs and over - the - counter complimentary medicines. Herb - drug interactions could affect pharmacokinetics and to increase or decrease their efficacy and toxicity. Pharmaco- kinetics play a very important roles in herb - drug interactions, including absorption, distribution, biotransforma- tion, and excretion. Liver is the main organ for drug metabolism and hepatic transporters play important roles in xenobiotie uptake and efflux. This paper discusses our recent studies on physiological variations of hepatic trans- porters including development, aging, pregnant and lactation and implications of hepatic transporters in rutaecarpine research.

关 键 词：肝脏转运体 中草药 药物相互作用 年龄和性别 妊娠和哺乳 时辰 

分 类 号：R234.2[医药卫生—中医学]